DegronMD - Q9C004(SPRY4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A102T	TCGA-AA-3877	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7139
p.H111Y	TCGA-B5-A1MX	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1111
p.T100M	TCGA-CG-4475	STAD	TCGA	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7423
p.T100M	TCGA-EY-A2OQ	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7423
p.T100M	SIDM00277	Acute Myeloid Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7423
p.T100M	EoL-1-cell	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7423
p.R89W	TCGA-EO-A22U	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0556
p.G93R	TCGA-H7-8501	HNSC	TCGA	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1667
p.G93R	SIDM01265	Plasma Cell Myeloma	GDSC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1667
p.G93R	MM1S	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1667
p.P95A	TCGA-W3-AA1O	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2222
p.S102R	DO229041	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7427
p.S100G	DO47813	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.5882
p.S103N	DO42336	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7069
p.R95C	DO223286	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2222
p.D105N	SIDM00683	Prostate Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2778
p.D105N	LNCaP-Clone-FGC	prostate	COSMIC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2778
p.I113N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0556
p.I113N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0556
p.P95L	SIDM01259	B-Lymphoblastic Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2222
p.P95L	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2222
p.P101L	SIDM00596	Endometrial Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7582
p.P101L	HEC-1	endometrium	COSMIC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.7582
p.P95S	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2222
p.P95S	NALM-6	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2222
p.R89Q	SIDM00476	Ovarian Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0556
p.R89Q	OV-17R	ovary	COSMIC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0556
p.S100T	ACH-002149	Ovarian Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.6005
p.S100T	KGN	ovary	COSMIC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation altering degron motif	0.6005
p.I90N	ACH-002256	Leukemia	CCLE	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0833
p.I90N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.0833

Kaplan plot for SPRY4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPRY4

UniProt ID: Q9C004

Entrez ID: 81848

Protein name: Protein sprouty homolog 4 (Spry-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPRY4 in