DegronMD - Q9C0H2(TTYH3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y501H	TCGA-CD-A4MG	STAD	TCGA	PPSY	ITCH	498:501	Mutation altering degron motif	0.7229
p.Y501H	DO48009	STAD	ICGC	PPSY	ITCH	498:501	Mutation altering degron motif	0.7229
p.L491V	TCGA-EJ-5524	PRAD	TCGA	PPSY	ITCH	498:501	Mutation rewiring degron network	0.1389
p.L491V	DO36284	PRAD	ICGC	PPSY	ITCH	498:501	Mutation rewiring degron network	0.1389
p.S503C	TCGA-G2-A2EO	BLCA	TCGA	PPSY	ITCH	498:501	Mutation rewiring degron network	0.2778
p.S503C	DO456	BLCA	ICGC	PPSY	ITCH	498:501	Mutation rewiring degron network	0.2778
p.N488S	TCGA-HT-7471	LGG	TCGA	PPSY	ITCH	498:501	Mutation rewiring degron network	0.0556
p.R494H	TCGA-NH-A5IV	COAD	TCGA	PPSY	ITCH	498:501	Mutation rewiring degron network	0.2222
p.R494H	DO49095	COAD	ICGC	PPSY	ITCH	498:501	Mutation rewiring degron network	0.2222
p.R494H	SIDM00839	Colorectal Carcinoma	GDSC	PPSY	ITCH	498:501	Mutation rewiring degron network	0.2222
p.R494H	ACH-000950	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	498:501	Mutation rewiring degron network	0.2222
p.R494H	LoVo	large intestine	COSMIC	PPSY	ITCH	498:501	Mutation rewiring degron network	0.2222
p.A511S	DO229028	LICA	ICGC	PPSY	ITCH	498:501	Mutation rewiring degron network	0.0556
p.S504I	DO229022	LICA	ICGC	PPSY	ITCH	498:501	Mutation rewiring degron network	0.25
p.M505I	DO229032	LICA	ICGC	PPSY	ITCH	498:501	Mutation rewiring degron network	0.2222
p.A511T	DO230934	LUSC	ICGC	PPSY	ITCH	498:501	Mutation rewiring degron network	0.0556
p.A511T	DO224581	LUSC	ICGC	PPSY	ITCH	498:501	Mutation rewiring degron network	0.0556
p.N488D	DO232224	PBCA	ICGC	PPSY	ITCH	498:501	Mutation rewiring degron network	0.0556
p.S496F	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PPSY	ITCH	498:501	Mutation blocking phosphorylation signal	0.7222
p.S496F	ACH-000636	Leukemia	CCLE	PPSY	ITCH	498:501	Mutation blocking phosphorylation signal	0.7222
p.S496F	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	498:501	Mutation blocking phosphorylation signal	0.7222
p.P498S	SIDM00781	Colorectal Carcinoma	GDSC	PPSY	ITCH	498:501	Mutation altering degron motif	0.6752
p.P498S	SIDM00780	Colorectal Carcinoma	GDSC	PPSY	ITCH	498:501	Mutation altering degron motif	0.6752
p.P498S	ACH-000967	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	498:501	Mutation altering degron motif	0.6752
p.P498S	ACH-001199	Colon/Colorectal Cancer	CCLE	PPSY	ITCH	498:501	Mutation altering degron motif	0.6752
p.P498S	SNU-C2B	large intestine	COSMIC	PPSY	ITCH	498:501	Mutation altering degron motif	0.6752
p.P499R	ACH-001413	Bladder Cancer	CCLE	PPSY	ITCH	498:501	Mutation altering degron motif	0.7512

Kaplan plot for TTYH3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTYH3

UniProt ID: Q9C0H2

Entrez ID: 80727

Protein name: Protein tweety homolog 3 (hTTY3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TTYH3 in