DegronMD - Q9H000(MKRN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S165N	TCGA-97-7938	LUAD	TCGA	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.1667
p.S165N	DO24329	LUAD	ICGC	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.1667
p.V158M	TCGA-AG-A002	READ	TCGA	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.6097
p.A150V	TCGA-AX-A1CE	UCEC	TCGA	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.3056
p.A150V	DO42280	UCEC	ICGC	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.3056
p.R152S	TCGA-D3-A2JP	SKCM	TCGA	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.7427
p.R152S	DO47407	SKCM	ICGC	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.7427
p.S153G	TCGA-DH-5144	LGG	TCGA	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.5882
p.S153G	DO22175	LGG	ICGC	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.5882
p.A150D	TCGA-DU-6392	LGG	TCGA	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.3056
p.A150D	DO22237	LGG	ICGC	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.3056
p.E167K	DO225274	BRCA	ICGC	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.1111
p.Q168K	DO230343	COCA	ICGC	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.0833
p.P144L	DO227987	COCA	ICGC	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.1389
p.D156Y	DO228952	LICA	ICGC	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation altering degron motif	0.6214
p.E141K	SIDM01611	Endometrial Carcinoma	GDSC	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.0556
p.G147R	ACH-000949	Gastric Cancer	CCLE	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.2222
p.G147R	TGBC11TKB	stomach	COSMIC	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.2222
p.D162N	ACH-000999	Colon/Colorectal Cancer	CCLE	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.25
p.D162N	SNU-1040	large intestine	COSMIC	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.25
p.P160T	BFTC-909	kidney	COSMIC	IRSGLDDVE	DEG_APCC_DBOX_1	151:159	Mutation rewiring degron network	0.3056

Kaplan plot for MKRN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MKRN2

UniProt ID: Q9H000

Entrez ID: 23609

Protein name: E3 ubiquitin-protein ligase makorin-2 (EC 2.3.2.27) (RING finger protein 62) (RING-type E3 ubiquitin transferase makorin-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MKRN2 in