DegronMD - Q9H0G5(NSRP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R335H	TCGA-A5-A2K3	UCEC	TCGA	DYR	CBL_MET	336:338	Mutation rewiring degron network	0.3056
p.R335H	DO43899	UCEC	ICGC	DYR	CBL_MET	336:338	Mutation rewiring degron network	0.3056
p.S343Y	TCGA-AX-A06F	UCEC	TCGA	DYR	CBL_MET	336:338	Mutation rewiring degron network	0.1944
p.S343Y	DO41752	UCEC	ICGC	DYR	CBL_MET	336:338	Mutation rewiring degron network	0.1944
p.R335S	TCGA-EE-A3AA	SKCM	TCGA	DYR	CBL_MET	336:338	Mutation rewiring degron network	0.3056
p.R335S	DO37571	SKCM	ICGC	DYR	CBL_MET	336:338	Mutation rewiring degron network	0.3056
p.R338W	TCGA-R5-A804	STAD	TCGA	DYR	CBL_MET	336:338	Mutation altering degron motif	0.8634
p.R338W	DO222344	STAD	ICGC	DYR	CBL_MET	336:338	Mutation altering degron motif	0.8634
p.R338W	SIDM00792	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	336:338	Mutation altering degron motif	0.8634
p.R338W	ACH-001719	Ovarian Cancer	CCLE	DYR	CBL_MET	336:338	Mutation altering degron motif	0.8634
p.R338W	ACH-002170	Lung Cancer	CCLE	DYR	CBL_MET	336:338	Mutation altering degron motif	0.8634
p.R338W	NCI-H1688	lung	COSMIC	DYR	CBL_MET	336:338	Mutation altering degron motif	0.8634
p.R341K	DO229227	THCA	ICGC	DYR	CBL_MET	336:338	Mutation rewiring degron network	0.25
p.D342N	SIDM00319	Melanoma	GDSC	DYR	CBL_MET	336:338	Mutation rewiring degron network	0.2222
p.D342N	SIDM00719	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	336:338	Mutation rewiring degron network	0.2222
p.D342N	SIDM00934	Pancreatic Carcinoma	GDSC	DYR	CBL_MET	336:338	Mutation rewiring degron network	0.2222
p.D342N	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	DYR	CBL_MET	336:338	Mutation rewiring degron network	0.2222
p.H331R	SIDM01608	Endometrial Carcinoma	GDSC	DYR	CBL_MET	336:338	Mutation rewiring degron network	0.1944
p.H331R	ACH-000990	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	336:338	Mutation rewiring degron network	0.1944

Kaplan plot for NSRP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NSRP1

UniProt ID: Q9H0G5

Entrez ID: 84081

Protein name: Nuclear speckle splicing regulatory protein 1 (Coiled-coil domain-containing protein 55) (Nuclear speckle-related protein 70) (NSrp70)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NSRP1 in