DegronMD - Q9H0I9(TKTL2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I302M	TCGA-96-7544	LUSC	TCGA	PPAY	ITCH	310:313	Mutation rewiring degron network	0.1111
p.I302M	DO26425	LUSC	ICGC	PPAY	ITCH	310:313	Mutation rewiring degron network	0.1111
p.D304N	TCGA-A5-A0G2	UCEC	TCGA	PPAY	ITCH	310:313	Mutation rewiring degron network	0.1667
p.D304N	DO41235	UCEC	ICGC	PPAY	ITCH	310:313	Mutation rewiring degron network	0.1667
p.D317E	TCGA-BH-A1EN	BRCA	TCGA	PPAY	ITCH	310:313	Mutation rewiring degron network	0.2222
p.D317E	DO3494	BRCA	ICGC	PPAY	ITCH	310:313	Mutation rewiring degron network	0.2222
p.A320V	TCGA-BP-4988	KIRC	TCGA	PPAY	ITCH	310:313	Mutation rewiring degron network	0.1389
p.A320V	DO17542	KIRC	ICGC	PPAY	ITCH	310:313	Mutation rewiring degron network	0.1389
p.P310A	TCGA-CS-4938	LGG	TCGA	PPAY	ITCH	310:313	Mutation altering degron motif	0.7503
p.P310A	DO22127	LGG	ICGC	PPAY	ITCH	310:313	Mutation altering degron motif	0.7503
p.I300V	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	310:313	Mutation rewiring degron network	0.0556
p.I300V	SIDM00094	Kidney Carcinoma	GDSC	PPAY	ITCH	310:313	Mutation rewiring degron network	0.0556
p.I300V	SIDM01387	Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	310:313	Mutation rewiring degron network	0.0556
p.P310Q	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	310:313	Mutation altering degron motif	0.7035
p.P310Q	ACH-000888	Lung Cancer	CCLE	PPAY	ITCH	310:313	Mutation altering degron motif	0.7035
p.P310Q	NCI-H1793	lung	COSMIC	PPAY	ITCH	310:313	Mutation altering degron motif	0.7035

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons