DegronMD - Q9H0N0(RAB6C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S224Y	TCGA-AA-3984	COAD	TCGA	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0833
p.S224Y	DO9002	COAD	ICGC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0833
p.P221H	TCGA-AJ-A3EK	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1667
p.P221H	DO41584	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1667
p.F225L	TCGA-AN-A046	BRCA	TCGA	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.F225L	DO1285	BRCA	ICGC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.P211L	TCGA-DA-A1HY	SKCM	TCGA	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7582
p.P211L	DO37409	SKCM	ICGC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7582
p.T216I	TCGA-DM-A28F	COAD	TCGA	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.3056
p.T216I	DO9828	COAD	ICGC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.3056
p.E203K	TCGA-EE-A2GM	SKCM	TCGA	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1111
p.E203K	DO37555	SKCM	ICGC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1111
p.G204W	TCGA-EO-A22R	UCEC	TCGA	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1389
p.G204W	DO42713	UCEC	ICGC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1389
p.Q219E	TCGA-JW-A5VL	CESC	TCGA	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2222
p.Q219E	DO49976	CESC	ICGC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2222
p.E203Q	DO218176	BRCA	ICGC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1111
p.S214Y	DO229010	COCA	ICGC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	DO229346	LAML	ICGC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	SIDM00529	Breast Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	SIDM00842	Colorectal Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	SIDM00215	Colorectal Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	SIDM00018	Acute Myeloid Leukemia	GDSC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	SIDM01128	Small Cell Lung Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	SIDM01042	Breast Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	SIDM00435	Acute Myeloid Leukemia	GDSC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	SIDM00279	Gastric Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	SIDM00628	Breast Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	SIDM00641	Burkitt's Lymphoma	GDSC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.S214Y	SIDM00192	Colorectal Carcinoma	GDSC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.712
p.G204R	DO233802	GACA	ICGC	PMSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1389

Kaplan plot for RAB6C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAB6C

UniProt ID: Q9H0N0

Entrez ID: 84084

Protein name: Ras-related protein Rab-6C (Rab6-like protein WTH3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAB6C in