DegronMD - Q9H1C7(CYSTM1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E4D	TCGA-78-8662	LUAD	TCGA	PPPY	ITCH	6:9	Mutation rewiring degron network	0.2778
p.E4D	DO45346	LUAD	ICGC	PPPY	ITCH	6:9	Mutation rewiring degron network	0.2778
p.E4Q	TCGA-A2-A25D	BRCA	TCGA	PPPY	ITCH	6:9	Mutation rewiring degron network	0.2778
p.E4Q	DO1262	BRCA	ICGC	PPPY	ITCH	6:9	Mutation rewiring degron network	0.2778
p.P6H	TCGA-AD-6964	COAD	TCGA	PPPY	ITCH	6:9	Mutation altering degron motif	0.7694
p.P6H	DO8360	COAD	ICGC	PPPY	ITCH	6:9	Mutation altering degron motif	0.7694
p.A16V	TCGA-AX-A06F	UCEC	TCGA	PPPY	ITCH	6:9	Mutation rewiring degron network	0.1389
p.A16V	DO41752	UCEC	ICGC	PPPY	ITCH	6:9	Mutation rewiring degron network	0.1389
p.T15M	TCGA-DU-6392	LGG	TCGA	PPPY	ITCH	6:9	Mutation rewiring degron network	0.1667
p.T15M	DO22237	LGG	ICGC	PPPY	ITCH	6:9	Mutation rewiring degron network	0.1667
p.P7A	TCGA-UY-A78P	BLCA	TCGA	PPPY	ITCH	6:9	Mutation altering degron motif	0.7503
p.P7A	DO219036	BLCA	ICGC	PPPY	ITCH	6:9	Mutation altering degron motif	0.7503

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons