DegronMD - Q9H1R2(DUSP15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R295C	DO44228	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.25
p.R295C	DO8826	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.25
p.R295C	DO47867	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.25
p.C293R	DO49929	CESC	ICGC	AASSS	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.3056
p.R262H	DO223732	CESC	ICGC	PGSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0833
p.R262H	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0833
p.R262H	SIDM00210	Ovarian Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0833
p.R262C	DO6290	CESC	ICGC	PGSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0833
p.R262C	DO233941	GACA	ICGC	PGSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0833
p.R295H	DO8103	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.25
p.R295H	DO38423	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.25
p.R295H	SIDM00217	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.25
p.R295H	SNU-1040	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.25
p.A289T	DO46657	PAAD	ICGC	AASSS	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.6028
p.A289T	SIDM00118	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.6028
p.S252L	DO38111	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.8778
p.S292P	DO38887	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.6752
p.S251R	DO229211	THCA	ICGC	PGSSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7427
p.L247I	DO42280	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.P263S	DO42280	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0556
p.S259L	DO41235	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.R295L	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.25
p.R295L	SIDM00210	Ovarian Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.25

Kaplan plot for DUSP15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DUSP15

UniProt ID: Q9H1R2

Entrez ID: 128853

Protein name: Dual specificity protein phosphatase 15 (EC 3.1.3.16) (EC 3.1.3.48) (VH1-related member Y) (Vaccinia virus VH1-related dual-specific protein phosphatase Y)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DUSP15 in