DegronMD - Q9H1R3(MYLK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L66Q	TCGA-13-0805	OV	TCGA	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.L66Q	DO28651	OV	ICGC	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.T71A	TCGA-55-A4DG	LUAD	TCGA	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.7139
p.T71A	DO26337	LUAD	ICGC	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.7139
p.Q74E	TCGA-60-2723	LUSC	TCGA	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.3056
p.Q74E	DO27152	LUSC	ICGC	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.3056
p.G78R	TCGA-DX-AB2E	SARC	TCGA	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1944
p.G78R	TCGA-EE-A2MR	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1944
p.G78R	DO220073	SARC	ICGC	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1944
p.G78R	DO37819	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1944
p.G78E	TCGA-EE-A2MR	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1944
p.G78E	DO37819	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1944
p.K77N	TCGA-LL-A8F5	BRCA	TCGA	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation substituting flanking lysine	0.3333
p.K77N	DO50068	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation substituting flanking lysine	0.3333
p.G80S	DO220906	MELA	ICGC	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1389
p.S72R	DO50727	ORCA	ICGC	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.7427
p.S70L	ACH-001982	Metastasis	CCLE	PSTSS	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.6556

Kaplan plot for MYLK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYLK2

UniProt ID: Q9H1R3

Entrez ID: 85366

Protein name: Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYLK2 in