DegronMD - Q9H2S9(IKZF4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D48E	TCGA-23-1124	OV	TCGA	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.1667
p.D48E	TCGA-AZ-6600	COAD	TCGA	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.1667
p.D48E	DO10774	COAD	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.1667
p.D48E	DO32596	OV	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.1667
p.R518W	TCGA-43-6773	LUSC	TCGA	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.1944
p.D343Y	TCGA-73-A9RS	LUAD	TCGA	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.6214
p.D343Y	SIDM00332	Breast Carcinoma	GDSC	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.6214
p.D343Y	MFM-223	breast	COSMIC	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.6214
p.R338H	TCGA-A5-A0G2	UCEC	TCGA	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.8244
p.R338H	TCGA-CM-5861	COAD	TCGA	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.8244
p.L94R	TCGA-AP-A0LM	UCEC	TCGA	VEMYSD	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.1389
p.L94R	TCGA-AP-A0LM	UCEC	TCGA	KVEMYSD	LIG_APCC_ABBAyCdc20_2	100:106	Mutation rewiring degron network	0.1667
p.R507Q	TCGA-AP-A0LT	UCEC	TCGA	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation altering degron motif	0.6218
p.E497V	TCGA-BS-A0V7	UCEC	TCGA	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.0833
p.V519A	TCGA-CG-5721	STAD	TCGA	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.1667
p.P40L	TCGA-D1-A1O7	UCEC	TCGA	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.7582
p.P40L	DO41139	UCEC	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.7582
p.K355N	TCGA-D3-A2JC	SKCM	TCGA	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation substituting flanking lysine	0.1667
p.G504W	TCGA-EB-A1NK	SKCM	TCGA	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2778
p.E354K	TCGA-EE-A2MM	SKCM	TCGA	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.0833
p.G352S	TCGA-FR-A3YO	SKCM	TCGA	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.1389
p.P44S	TCGA-FW-A3R5	SKCM	TCGA	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.2778
p.P44S	DO37406	SKCM	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.2778
p.E497K	TCGA-L5-A8NL	ESCA	TCGA	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.0833
p.Q45R	TCGA-VQ-A8PX	STAD	TCGA	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.25
p.Q45R	DO51778	STAD	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.25
p.E25D	DO2665	BRCA	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.1111
p.R337C	DO9498	COAD	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.8301
p.R337C	DO41331	UCEC	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.8301
p.T351M	DO230311	COCA	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.1667
p.R24W	DO222842	COCA	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.G98A	DO229016	COCA	ICGC	VEMYSD	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.25
p.G98A	DO229016	COCA	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	100:106	Mutation rewiring degron network	0.2778
p.F42V	DO234303	ESAD	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.5957
p.S35L	DO223072	ESCA	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.7667
p.G28R	DO233089	GACA	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.1944
p.G28R	DO233757	GACA	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.1944
p.Q25L	DO233270	GACA	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.1111
p.P104S	DO233889	GACA	ICGC	VEMYSD	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.6752
p.P104S	DO233889	GACA	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	100:106	Mutation altering degron motif	0.6752
p.G37E	DO233823	GACA	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.6087
p.P104T	DO14398	HNSC	ICGC	VEMYSD	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.7031
p.P104T	DO14398	HNSC	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	100:106	Mutation altering degron motif	0.7031
p.G508V	DO228985	LICA	ICGC	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation altering degron motif	0.6421
p.G332V	DO229018	LICA	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.1944
p.R24L	DO229019	LICA	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.G519C	DO229028	LICA	ICGC	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.1667
p.C515F	DO229022	LICA	ICGC	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2778
p.C515F	DO229041	LICA	ICGC	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2778
p.C94F	DO229025	LICA	ICGC	VEMYSD	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.1389
p.C94F	DO229025	LICA	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	100:106	Mutation rewiring degron network	0.1667
p.R337L	DO231104	LUSC	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.8428
p.I347M	DO30180	OV	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.2778
p.R108W	DO51407	PRAD	ICGC	VEMYSD	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.2778
p.R108W	DO51407	PRAD	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	100:106	Mutation rewiring degron network	0.2778
p.R108Q	DO38400	STAD	ICGC	VEMYSD	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.2778
p.R108Q	DO38400	STAD	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	100:106	Mutation rewiring degron network	0.2778
p.R108Q	DO41871	UCEC	ICGC	VEMYSD	LIG_APCC_ABBA_1	101:106	Mutation rewiring degron network	0.2778
p.R108Q	DO41871	UCEC	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	100:106	Mutation rewiring degron network	0.2778
p.M504I	DO51761	STAD	ICGC	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2778
p.L350P	DO38679	STAD	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.1944
p.G106S	DO47911	STAD	ICGC	VEMYSD	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.6993
p.G106S	DO47911	STAD	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	100:106	Mutation altering degron motif	0.6993
p.L49R	DO43306	UCEC	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.1389
p.R518Q	SIDM00216	Colorectal Carcinoma	GDSC	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.1944
p.R518Q	SNU-175	large intestine	COSMIC	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.1944
p.L517F	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2222
p.L517F	ACH-000981	Leukemia	CCLE	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2222
p.L517F	DND-41	haematopoietic and lymphoid tissue	COSMIC	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.2222
p.R24Q	SIDM00662	Melanoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM00623	Other Blood Cancers	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM00803	Kidney Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM00472	Ovarian Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM00507	Other Solid Cancers	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM00881	Breast Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM00094	Kidney Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM00346	Chronic Myelogenous Leukemia	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM00148	Breast Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM00730	Small Cell Lung Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM00943	Pancreatic Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM01140	Ovarian Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM00975	Melanoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM00100	Mesothelioma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM00209	Glioblastoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.R24Q	SIDM01525	Acute Myeloid Leukemia	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0833
p.D33E	SIDM00845	Burkitt's Lymphoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.5647
p.D33E	Daudi	haematopoietic and lymphoid tissue	COSMIC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.5647
p.P34L	SIDM00845	Burkitt's Lymphoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.6471
p.P34L	Daudi	haematopoietic and lymphoid tissue	COSMIC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.6471
p.V39A	SIDM00845	Burkitt's Lymphoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.6936
p.V39A	SIDM01519	Head and Neck Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.6936
p.V39A	Daudi	haematopoietic and lymphoid tissue	COSMIC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.6936
p.H23Y	SIDM00475	Ovarian Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation rewiring degron network	0.0556
p.G521C	SIDM00445	Esophageal Carcinoma	GDSC	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.1111
p.G521C	OACp4C	oesophagus	COSMIC	LRGTPGPS	DEG_SCF_FBW7_1	506:513	Mutation rewiring degron network	0.1111
p.P38S	ACH-000750	Skin Cancer	CCLE	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.6752
p.P38S	LOXIMVI	skin	COSMIC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.6752
p.T351R	ACH-000790	Lung Cancer	CCLE	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.1667
p.T351R	SHP-77	lung	COSMIC	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation rewiring degron network	0.1667
p.G105E	ACH-000899	Skin Cancer	CCLE	VEMYSD	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.7199
p.G105E	ACH-000899	Skin Cancer	CCLE	KVEMYSD	LIG_APCC_ABBAyCdc20_2	100:106	Mutation altering degron motif	0.7199

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IKZF4

UniProt ID: Q9H2S9

Entrez ID: 64375

Protein name: Zinc finger protein Eos (Ikaros family zinc finger protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IKZF4 in