DegronMD - Q9H2S9(IKZF4)

FUNCTION: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and p... View more >>

GO - Biological processes (BP): negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein homooligomerization [GO:0051260]; regulation of transcription by RNA polymerase II [GO:0006357]

GO - Molecular function (MF): bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity [GO:0003700]; protein domain specific binding [GO:0019904]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]

GO - Cellular component (CC): nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
MRFSLSDLP	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Zinc finger protein Eos	337:345	More..
DPSGGCVPDF	DEG_COP1_1	COP1	Zinc finger protein Eos	33:42	More..
LRGTPGPS	DEG_SCF_FBW7_1	FBXW7	Zinc finger protein Eos	506:513	More..
VEMYSD	LIG_APCC_ABBA_1	APC,CDC20,FZR1	Zinc finger protein Eos	101:106	More..
KVEMYSD	LIG_APCC_ABBAyCdc20_2	APC,CDC20,FZR1	Zinc finger protein Eos	100:106	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R337L	DO231104	LUSC	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.8428
p.R337C	DO9498	COAD	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.8301
p.R337C	DO41331	UCEC	ICGC	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.8301
p.R338H	TCGA-A5-A0G2	UCEC	TCGA	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.8244
p.R338H	TCGA-CM-5861	COAD	TCGA	MRFSLSDLP	DEG_APCC_DBOX_1	337:345	Mutation altering degron motif	0.8244
p.S35L	DO223072	ESCA	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.7667
p.P40L	TCGA-D1-A1O7	UCEC	TCGA	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.7582
p.P40L	DO41139	UCEC	ICGC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.7582
p.G105E	ACH-000899	Skin Cancer	CCLE	VEMYSD	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.7199
p.G105E	ACH-000899	Skin Cancer	CCLE	KVEMYSD	LIG_APCC_ABBAyCdc20_2	100:106	Mutation altering degron motif	0.7199
p.P104T	DO14398	HNSC	ICGC	VEMYSD	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.7031
p.P104T	DO14398	HNSC	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	100:106	Mutation altering degron motif	0.7031
p.G106S	DO47911	STAD	ICGC	VEMYSD	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.6993
p.G106S	DO47911	STAD	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	100:106	Mutation altering degron motif	0.6993
p.V39A	SIDM00845	Burkitt's Lymphoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.6936
p.V39A	SIDM01519	Head and Neck Carcinoma	GDSC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.6936
p.V39A	Daudi	haematopoietic and lymphoid tissue	COSMIC	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.6936
p.P104S	DO233889	GACA	ICGC	VEMYSD	LIG_APCC_ABBA_1	101:106	Mutation altering degron motif	0.6752
p.P104S	DO233889	GACA	ICGC	KVEMYSD	LIG_APCC_ABBAyCdc20_2	100:106	Mutation altering degron motif	0.6752
p.P38S	ACH-000750	Skin Cancer	CCLE	DPSGGCVPDF	DEG_COP1_1	33:42	Mutation altering degron motif	0.6752

Showing 1 to 20 of 102 entries

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No resistance data available for this Degron.

Kaplan plot for IKZF4 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

IKZF4

UniProt ID: Q9H2S9

Entrez ID: 64375

Protein name: Zinc finger protein Eos (Ikaros family zinc finger protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for IKZF4 in