DegronMD - Q9H3Y0(R3HDML)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S238N	TCGA-44-5644	LUAD	TCGA	PPSY	ITCH	229:232	Mutation rewiring degron network	0.1667
p.S238N	DO25153	LUAD	ICGC	PPSY	ITCH	229:232	Mutation rewiring degron network	0.1667
p.M221K	TCGA-55-8507	LUAD	TCGA	PPSY	ITCH	229:232	Mutation rewiring degron network	0.1111
p.M221K	DO45412	LUAD	ICGC	PPSY	ITCH	229:232	Mutation rewiring degron network	0.1111
p.Q233E	TCGA-AO-A03M	BRCA	TCGA	PPSY	ITCH	229:232	Mutation rewiring degron network	0.3056
p.Q233E	DO2216	BRCA	ICGC	PPSY	ITCH	229:232	Mutation rewiring degron network	0.3056
p.P224S	TCGA-BG-A222	UCEC	TCGA	PPSY	ITCH	229:232	Mutation rewiring degron network	0.1944
p.P224S	DO42977	UCEC	ICGC	PPSY	ITCH	229:232	Mutation rewiring degron network	0.1944
p.Y219C	TCGA-DU-7013	LGG	TCGA	PPSY	ITCH	229:232	Mutation rewiring degron network	0.0556
p.Y219C	DO22217	LGG	ICGC	PPSY	ITCH	229:232	Mutation rewiring degron network	0.0556
p.Y219C	SIDM01608	Endometrial Carcinoma	GDSC	PPSY	ITCH	229:232	Mutation rewiring degron network	0.0556
p.Y219C	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	229:232	Mutation rewiring degron network	0.0556
p.S235R	TCGA-EE-A181	SKCM	TCGA	PPSY	ITCH	229:232	Mutation rewiring degron network	0.25
p.S235R	DO37444	SKCM	ICGC	PPSY	ITCH	229:232	Mutation rewiring degron network	0.25
p.C241Y	TCGA-HF-7133	STAD	TCGA	PPSY	ITCH	229:232	Mutation rewiring degron network	0.0833
p.C241Y	DO38819	STAD	ICGC	PPSY	ITCH	229:232	Mutation rewiring degron network	0.0833
p.K223N	DO229027	LICA	ICGC	PPSY	ITCH	229:232	Mutation substituting flanking lysine	0.2778
p.M221I	DO222843	MELA	ICGC	PPSY	ITCH	229:232	Mutation rewiring degron network	0.1111
p.P230R	SIDM00340	Plasma Cell Myeloma	GDSC	PPSY	ITCH	229:232	Mutation altering degron motif	0.7512
p.P230R	ACH-000204	Myeloma	CCLE	PPSY	ITCH	229:232	Mutation altering degron motif	0.7512
p.P230R	LP-1	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	229:232	Mutation altering degron motif	0.7512

Kaplan plot for R3HDML in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

R3HDML

UniProt ID: Q9H3Y0

Entrez ID: 140902

Protein name: Peptidase inhibitor R3HDML (Cysteine-rich secretory protein R3HDML)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for R3HDML in