DegronMD - Q9H693(C16orf95)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R132H	DO233634	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.3056
p.D142E	DO228976	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1944
p.L129I	DO228978	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	133:137	Mutation blocking phosphorylation signal	0.6667
p.H131N	DO229024	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.2778
p.H131N	DO229034	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.2778
p.R147W	DO229054	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0556
p.G134A	DO228338	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.754
p.G134A	SIDM00948	Burkitt's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.754
p.R136H	DO232761	PBCA	ICGC	PSSSS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.8244
p.V127A	DO38376	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1667
p.P147L	DO229259	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0556
p.P140H	SIDM00680	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.25
p.G124R	ACH-000877	Lymphoma	CCLE	PSSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833
p.G124R	ACH-001064	Lymphoma	CCLE	PSSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833
p.Y146H	ACH-000988	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons