DegronMD - Q9H6T0(ESRP2)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T578S	TCGA-B0-4811	KIRC	TCGA	PPTY	ITCH	584:587	Mutation substituting flanking lysine	0.2778
p.P575L	TCGA-EB-A85I	SKCM	TCGA	PPTY	ITCH	584:587	Mutation rewiring degron network	0.0833
p.P596T	TCGA-G5-6233	READ	TCGA	PPTY	ITCH	584:587	Mutation rewiring degron network	0.0833
p.T588S	DO17552	KIRC	ICGC	PPTY	ITCH	584:587	Mutation rewiring degron network	0.3056
p.P576T	DO229048	LICA	ICGC	PPTY	ITCH	584:587	Mutation rewiring degron network	0.1111
p.T589N	DO50662	ORCA	ICGC	PPTY	ITCH	584:587	Mutation rewiring degron network	0.2778
p.P585L	DO50296	SKCM	ICGC	PPTY	ITCH	584:587	Mutation altering degron motif	0.7582
p.L594V	SIDM00155	Head and Neck Carcinoma	GDSC	PPTY	ITCH	584:587	Mutation rewiring degron network	0.1389
p.L594V	PCI-38	upper aerodigestive tract	COSMIC	PPTY	ITCH	584:587	Mutation rewiring degron network	0.1389
p.T585M	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PPTY	ITCH	584:587	Mutation altering degron motif	0.7423
p.T585M	NCI-H1573	lung	COSMIC	PPTY	ITCH	584:587	Mutation altering degron motif	0.7423
p.P584T	SIDM01229	Neuroblastoma	GDSC	PPTY	ITCH	584:587	Mutation altering degron motif	0.7031
p.P584T	BE2-M17	autonomic ganglia	COSMIC	PPTY	ITCH	584:587	Mutation altering degron motif	0.7031
p.T595M	ACH-000916	Lung Cancer	CCLE	PPTY	ITCH	584:587	Mutation rewiring degron network	0.1111
p.T595M	NCI-H1573	lung	COSMIC	PPTY	ITCH	584:587	Mutation rewiring degron network	0.1111
p.P594T	ACH-002217	Neuroblastoma	CCLE	PPTY	ITCH	584:587	Mutation rewiring degron network	0.1389
p.P594T	BE2-M17	autonomic ganglia	COSMIC	PPTY	ITCH	584:587	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons