DegronMD - Q9H773(DCTPP1)

DCTPP1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H132Q	TCGA-B5-A0JY	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.2778
p.R135C	TCGA-MT-A51X	HNSC	TCGA	ARSSS	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.719
p.R126W	SIDM02059	Colorectal Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1111
p.K140N	SIDM00433	T-Lymphoblastic Leukemia	GDSC	ARSSS	DEG_SPOP_SBC_1	134:138	Mutation blocking ubiquitination signal	0.7222
p.K140N	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	ARSSS	DEG_SPOP_SBC_1	134:138	Mutation blocking ubiquitination signal	0.7222
p.R139C	SIDM00079	Ovarian Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.R139C	SK-OV-3	ovary	COSMIC	ARSSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.R135H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	ARSSS	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.7133
p.R135H	PF-382	haematopoietic and lymphoid tissue	COSMIC	ARSSS	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.7133
p.R139L	SIDM00192	Colorectal Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.R139L	SIDM01343	Gastric Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc