DegronMD - Q9H7V2(SYNDIG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I26T	TCGA-18-3421	LUSC	TCGA	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0833
p.I26T	DO27652	LUSC	ICGC	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0833
p.A45V	TCGA-AP-A0LM	UCEC	TCGA	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.2778
p.A45V	TCGA-HG-A2PA	CESC	TCGA	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.2778
p.A45V	DO6311	CESC	ICGC	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.2778
p.A45V	DO43306	UCEC	ICGC	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.2778
p.D37Y	TCGA-B5-A11E	UCEC	TCGA	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6214
p.D37Y	DO41644	UCEC	ICGC	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6214
p.R52W	TCGA-BG-A2L7	UCEC	TCGA	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0833
p.R52W	DO42344	UCEC	ICGC	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0833
p.E34K	TCGA-FW-A3R5	SKCM	TCGA	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.3056
p.E34K	DO37406	SKCM	ICGC	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.3056
p.R36T	TCGA-N9-A4Q7	UCS	TCGA	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.7876
p.R36T	DO222432	ESCA	ICGC	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.7876
p.S35R	DO234319	ESAD	ICGC	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6316
p.N30T	DO233287	GACA	ICGC	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.G38C	DO229041	LICA	ICGC	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6489
p.D37V	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6674
p.D37V	ACH-000669	Lung Cancer	CCLE	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6674
p.D37V	SW900	lung	COSMIC	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6674
p.A33P	SIDM01690	Plasma Cell Myeloma	GDSC	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.2778
p.A33P	ACH-000453	Myeloma	CCLE	SRDGLVSVY	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.2778

Kaplan plot for SYNDIG1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYNDIG1

UniProt ID: Q9H7V2

Entrez ID: 79953

Protein name: Synapse differentiation-inducing gene protein 1 (SynDIG1) (Dispanin subfamily C member 2) (DSPC2) (Transmembrane protein 90B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYNDIG1 in