DegronMD - Q9H869(YY1AP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R481W	TCGA-06-5416	GBM	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.8634
p.R481W	TCGA-B5-A1MW	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.8634
p.R481W	TCGA-D1-A177	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.8634
p.Q283R	TCGA-55-5899	LUAD	TCGA	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation altering degron motif	0.7329
p.Q283R	TCGA-55-5899	LUAD	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation altering degron motif	0.7329
p.E479K	TCGA-55-8208	LUAD	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7022
p.R481Q	TCGA-66-2758	LUSC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7329
p.R481Q	SIDM00057	Neuroblastoma	GDSC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7329
p.R481Q	SIDM00552	Rhabdomyosarcoma	GDSC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7329
p.R481Q	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7329
p.R481Q	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7329
p.R481Q	SIDM01559	Melanoma	GDSC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7329
p.P745S	TCGA-94-A5I6	LUSC	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	754:762	Mutation rewiring degron network	0.0833
p.L473M	TCGA-AP-A1DV	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation rewiring degron network	0.2778
p.D485N	TCGA-AX-A1CA	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation rewiring degron network	0.25
p.L465F	TCGA-B5-A3FC	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation rewiring degron network	0.0556
p.L288P	TCGA-B5-A3FC	UCEC	TCGA	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation rewiring degron network	0.25
p.L288P	TCGA-B5-A3FC	UCEC	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation rewiring degron network	0.25
p.S269N	TCGA-BG-A2L7	UCEC	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation substituting flanking lysine	0.1667
p.E478V	TCGA-BP-5191	KIRC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7693
p.S760Y	TCGA-BS-A0UF	UCEC	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	754:762	Mutation altering degron motif	0.712
p.P466S	TCGA-D8-A1XK	BRCA	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation blocking phosphorylation signal	0.5278
p.S285C	TCGA-DG-A2KK	CESC	TCGA	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation altering degron motif	0.7541
p.S285C	TCGA-DG-A2KK	CESC	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation altering degron motif	0.7541
p.S30T	TCGA-DX-A1L2	SARC	TCGA	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation blocking phosphorylation signal	0.5
p.S30T	DO219951	SARC	ICGC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation blocking phosphorylation signal	0.5
p.S30T	ACH-000978	Endometrial/Uterine Cancer	CCLE	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation blocking phosphorylation signal	0.5
p.S30T	EN	endometrium	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation blocking phosphorylation signal	0.5
p.R55L	TCGA-EK-A3GK	CESC	TCGA	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation rewiring degron network	0.1111
p.R55L	DO49964	CESC	ICGC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation rewiring degron network	0.1111
p.E478D	TCGA-EO-A3B0	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.6758
p.A487V	TCGA-EY-A1GU	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation rewiring degron network	0.1944
p.G279E	TCGA-GS-A9TZ	DLBC	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation altering degron motif	0.7199
p.V761L	TCGA-LL-A7SZ	BRCA	TCGA	GRQALEPLP	DEG_APCC_DBOX_1	754:762	Mutation altering degron motif	0.6765
p.E277Q	TCGA-P3-A5Q5	HNSC	TCGA	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation rewiring degron network	0.25
p.E277Q	TCGA-P3-A5Q5	HNSC	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation rewiring degron network	0.2778
p.A272P	DO218998	BLCA	ICGC	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation rewiring degron network	0.1111
p.A272P	DO218998	BLCA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation rewiring degron network	0.1389
p.R273H	DO9010	COAD	ICGC	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation rewiring degron network	0.1389
p.R273H	DO9010	COAD	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation rewiring degron network	0.1667
p.R273H	IST-MES1	pleura	COSMIC	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation rewiring degron network	0.1389
p.R273H	IST-MES1	pleura	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation rewiring degron network	0.1667
p.E744A	DO10244	COAD	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	754:762	Mutation rewiring degron network	0.0556
p.S747G	DO7977	COAD	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	754:762	Mutation rewiring degron network	0.1389
p.A481V	DO222769	COCA	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.6936
p.T477S	DO233923	GACA	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7116
p.N34K	DO10880	GBM	ICGC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation rewiring degron network	0.1667
p.N34K	HCE-4	oesophagus	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation rewiring degron network	0.1667
p.M284K	DO20893	KIRP	ICGC	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation altering degron motif	0.8062
p.M284K	DO20893	KIRP	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation altering degron motif	0.8062
p.R42W	DO22237	LGG	ICGC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation altering degron motif	0.8634
p.R273S	DO228952	LICA	ICGC	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation rewiring degron network	0.1389
p.R273S	DO228952	LICA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation rewiring degron network	0.1667
p.R273S	DO229009	LICA	ICGC	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation rewiring degron network	0.1389
p.R273S	DO229009	LICA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation rewiring degron network	0.1667
p.S478Y	DO229027	LICA	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.712
p.N283K	DO229032	LICA	ICGC	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation altering degron motif	0.6918
p.N283K	DO229032	LICA	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation altering degron motif	0.6918
p.H55Y	DO44832	LICA	ICGC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation rewiring degron network	0.1111
p.E53G	DO231563	LINC	ICGC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation rewiring degron network	0.1667
p.F43V	DO46657	PAAD	ICGC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation altering degron motif	0.7068
p.E53D	DO46901	RECA	ICGC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation rewiring degron network	0.1667
p.V487A	DO37861	SKCM	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation rewiring degron network	0.1944
p.R489I	DO39421	THCA	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation rewiring degron network	0.1389
p.L750I	DO219773	UCEC	ICGC	GRQALEPLP	DEG_APCC_DBOX_1	754:762	Mutation blocking ubiquitination signal	0.6667
p.G484S	DO43073	UCEC	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation rewiring degron network	0.2778
p.P468S	DO43250	UCEC	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation rewiring degron network	0.1389
p.D465N	DO42873	UCEC	ICGC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation rewiring degron network	0.0556
p.L46P	DO41903	UCEC	ICGC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation altering degron motif	0.7582
p.R42L	DO41999	UCEC	ICGC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation altering degron motif	0.8428
p.N293S	SIDM02026	Colorectal Carcinoma	GDSC	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation blocking ubiquitination signal	0.5556
p.N293S	SIDM02026	Colorectal Carcinoma	GDSC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation blocking ubiquitination signal	0.5556
p.P40L	SIDM00234	Other Solid Cancers	GDSC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation altering degron motif	0.7582
p.P40L	TC-YIK	cervix	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation altering degron motif	0.7582
p.S31T	SIDM01203	Other Solid Cancers	GDSC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation rewiring degron network	0.0833
p.S31T	NTERA-2_cl_D1	testis	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation rewiring degron network	0.0833
p.P49T	ACH-000093	Pancreatic Cancer	CCLE	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation rewiring degron network	0.2778
p.K269N	ACH-000910	Breast Cancer	CCLE	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation substituting flanking lysine	0.1667
p.K269N	MDA-MB-453	breast	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation substituting flanking lysine	0.1667
p.N272S	ACH-000978	Endometrial/Uterine Cancer	CCLE	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation rewiring degron network	0.1111
p.N272S	ACH-000978	Endometrial/Uterine Cancer	CCLE	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation rewiring degron network	0.1389
p.N272S	EN	endometrium	COSMIC	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation rewiring degron network	0.1111
p.N272S	EN	endometrium	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation rewiring degron network	0.1389
p.A42P	ACH-001338	Neuroblastoma	CCLE	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation altering degron motif	0.6392
p.A42P	CHP-134	autonomic ganglia	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation altering degron motif	0.6392
p.A41T	ACH-001338	Neuroblastoma	CCLE	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation altering degron motif	0.6028
p.A41T	CHP-134	autonomic ganglia	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation altering degron motif	0.6028
p.L52V	ACH-002234	Head and Neck Cancer	CCLE	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation rewiring degron network	0.1944
p.L52V	DOK	upper aerodigestive tract	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation rewiring degron network	0.1944
p.M475I	NCI-H128	lung	COSMIC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7618
p.F35C	SCH	stomach	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation rewiring degron network	0.1944
p.R273C	NCI-H630	large intestine	COSMIC	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation rewiring degron network	0.1389
p.R273C	NCI-H630	large intestine	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation rewiring degron network	0.1667
p.I479S	RS4-11	haematopoietic and lymphoid tissue	COSMIC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7341
p.A33T	SW1417	large intestine	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation rewiring degron network	0.1389
p.R491Q	A204	soft tissue	COSMIC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation blocking ubiquitination signal	0.5278
p.P287A	MDA-MB-330	breast	COSMIC	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation rewiring degron network	0.2778
p.P287A	MDA-MB-330	breast	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation rewiring degron network	0.2778
p.N283S	EN	endometrium	COSMIC	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation altering degron motif	0.7069
p.N283S	EN	endometrium	COSMIC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation altering degron motif	0.7069
p.M466I	NCI-H128	lung	COSMIC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation blocking phosphorylation signal	0.5278
p.D758G	SW872	soft tissue	COSMIC	GRQALEPLP	DEG_APCC_DBOX_1	754:762	Mutation altering degron motif	0.7198
p.M755V	NCI-H3122	lung	COSMIC	GRQALEPLP	DEG_APCC_DBOX_1	754:762	Mutation altering degron motif	0.7208
p.M486I	NCI-H128	lung	COSMIC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation rewiring degron network	0.2222
p.P760Q	SK-UT-1	soft tissue	COSMIC	GRQALEPLP	DEG_APCC_DBOX_1	754:762	Mutation altering degron motif	0.5924
p.E753K	THP-1	haematopoietic and lymphoid tissue	COSMIC	GRQALEPLP	DEG_APCC_DBOX_1	754:762	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

YY1AP1

UniProt ID: Q9H869

Entrez ID: 55249

Protein name: YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for YY1AP1 in