DegronMD - Q9H869(YY1AP1)

FUNCTION: Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). {ECO:0000269|PubMed:14744866, ECO:0000269|PubMed:17541814, ECO:0000269|PubMed:27939641}.

GO - Biological processes (BP): cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; regulation of cell cycle [GO:0051726]; regulation of transcription, DNA-templated [GO:0006355]

GO - Molecular function (MF): transcription coregulator activity [GO:0003712]

GO - Cellular component (CC): cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R481W	TCGA-06-5416	GBM	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.8634
p.R481W	TCGA-B5-A1MW	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.8634
p.R481W	TCGA-D1-A177	UCEC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.8634
p.R42W	DO22237	LGG	ICGC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation altering degron motif	0.8634
p.R42L	DO41999	UCEC	ICGC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation altering degron motif	0.8428
p.M284K	DO20893	KIRP	ICGC	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation altering degron motif	0.8062
p.M284K	DO20893	KIRP	ICGC	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation altering degron motif	0.8062
p.E478V	TCGA-BP-5191	KIRC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7693
p.M475I	NCI-H128	lung	COSMIC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7618
p.L46P	DO41903	UCEC	ICGC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation altering degron motif	0.7582
p.P40L	SIDM00234	Other Solid Cancers	GDSC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation altering degron motif	0.7582
p.P40L	TC-YIK	cervix	COSMIC	LAATPSSS	DEG_SCF_FBW7_1	40:47	Mutation altering degron motif	0.7582
p.S285C	TCGA-DG-A2KK	CESC	TCGA	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation altering degron motif	0.7541
p.S285C	TCGA-DG-A2KK	CESC	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation altering degron motif	0.7541
p.I479S	RS4-11	haematopoietic and lymphoid tissue	COSMIC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7341
p.Q283R	TCGA-55-5899	LUAD	TCGA	VFMYPE	LIG_APCC_ABBA_1	280:285	Mutation altering degron motif	0.7329
p.Q283R	TCGA-55-5899	LUAD	TCGA	KVFMYPE	LIG_APCC_ABBAyCdc20_2	279:285	Mutation altering degron motif	0.7329
p.R481Q	TCGA-66-2758	LUSC	TCGA	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7329
p.R481Q	SIDM00057	Neuroblastoma	GDSC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7329
p.R481Q	SIDM00552	Rhabdomyosarcoma	GDSC	PGKTPAQS	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7329

Showing 1 to 20 of 106 entries

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Kaplan plot for YY1AP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

YY1AP1

UniProt ID: Q9H869

Entrez ID: 55249

Protein name: YY1-associated protein 1 (Hepatocellular carcinoma susceptibility protein) (Hepatocellular carcinoma-associated protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for YY1AP1 in