DegronMD - Q9H9P5(UNKL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S558L	TCGA-A5-A0VP	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	554:558	Mutation altering degron motif	0.7667
p.S558L	DO42600	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	554:558	Mutation altering degron motif	0.7667
p.S557Y	TCGA-AP-A1DV	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	554:558	Mutation altering degron motif	0.712
p.S557Y	DO43186	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	554:558	Mutation altering degron motif	0.712
p.N563D	TCGA-CJ-5678	KIRC	TCGA	PPSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.1944
p.N563D	DO16891	KIRC	ICGC	PPSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.1944
p.S558W	TCGA-PE-A5DE	BRCA	TCGA	PPSSS	DEG_SPOP_SBC_1	554:558	Mutation altering degron motif	0.7874
p.S558W	DO219643	BRCA	ICGC	PPSSS	DEG_SPOP_SBC_1	554:558	Mutation altering degron motif	0.7874
p.S558W	DO230524	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	554:558	Mutation altering degron motif	0.7874
p.P406L	TCGA-SL-A6JA	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.25
p.P406L	DO219787	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.25
p.A410T	DO10324	COAD	ICGC	PASST	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.6028
p.G555S	DO230312	COCA	ICGC	PPSSS	DEG_SPOP_SBC_1	554:558	Mutation altering degron motif	0.6993
p.G555S	DO222755	COCA	ICGC	PPSSS	DEG_SPOP_SBC_1	554:558	Mutation altering degron motif	0.6993
p.G555S	DO234462	ESAD	ICGC	PPSSS	DEG_SPOP_SBC_1	554:558	Mutation altering degron motif	0.6993
p.F401L	DO50450	ESAD	ICGC	PASST	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1111
p.A421E	DO229009	LICA	ICGC	PASST	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1111
p.H554R	DO38404	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	554:558	Mutation altering degron motif	0.8244
p.V417F	DO229092	THCA	ICGC	PASST	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.2222
p.G422S	SIDM02050	Colorectal Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0833
p.A402V	SIDM02072	Colorectal Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.V420I	SIDM01081	Oral Cavity Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.V420I	SIDM00049	Colorectal Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1389
p.A399V	SIDM00217	Colorectal Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0556
p.R403G	ACH-000395	Lung Cancer	CCLE	PASST	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1667
p.L407P	ACH-000567	Lymphoma	CCLE	PASST	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.2778
p.S560F	ACH-000929	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.2778
p.S560F	NCI-H2110	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	554:558	Mutation rewiring degron network	0.2778
p.A399T	ACH-000984	Endometrial/Uterine Cancer	CCLE	PASST	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.0556
p.R403C	ACH-000990	Endometrial/Uterine Cancer	CCLE	PASST	DEG_SPOP_SBC_1	409:413	Mutation rewiring degron network	0.1667
p.S412N	ACH-000995	Leukemia	CCLE	PASST	DEG_SPOP_SBC_1	409:413	Mutation altering degron motif	0.7069

Kaplan plot for UNKL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UNKL

UniProt ID: Q9H9P5

Entrez ID: 64718

Protein name: Putative E3 ubiquitin-protein ligase UNKL (EC 2.3.2.-) (RING finger protein unkempt-like) (Zinc finger CCCH domain-containing protein 5-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UNKL in