DegronMD - Q9HAS0(C17orf75)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P32S	TCGA-B5-A3FC	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	32:36	Mutation altering degron motif	0.6752
p.P32S	DO41871	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	32:36	Mutation altering degron motif	0.6752
p.Y43C	TCGA-G3-AAV4	LIHC	TCGA	PPSSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.1389
p.Y43C	DO52298	LIHC	ICGC	PPSSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.1389
p.E26K	DO228246	BRCA	ICGC	PPSSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.1667
p.E26K	SIDM00807	Bladder Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.1667
p.E26K	ACH-000905	Bladder Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.1667
p.S42R	DO229024	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.1667
p.S24L	DO220898	MELA	ICGC	PPSSS	DEG_SPOP_SBC_1	32:36	Mutation blocking phosphorylation signal	0.5556
p.S35T	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	32:36	Mutation altering degron motif	0.6005
p.R29T	SIDM00807	Bladder Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.25
p.R29T	ACH-000905	Bladder Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons