DegronMD - Q9HAZ1(CLK4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E75K	TCGA-AP-A0LM	UCEC	TCGA	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.1389
p.E75K	TCGA-EI-6917	READ	TCGA	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.1389
p.E75K	DO36881	READ	ICGC	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.1389
p.E75K	DO43306	UCEC	ICGC	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.1389
p.R65Q	TCGA-AP-A0LM	UCEC	TCGA	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.3056
p.R65Q	DO43306	UCEC	ICGC	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.3056
p.R70W	TCGA-DF-A2KU	UCEC	TCGA	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.2778
p.R70W	DO223286	UCEC	ICGC	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.2778
p.R77K	TCGA-DV-5566	KIRC	TCGA	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.0833
p.R77K	DO18651	KIRC	ICGC	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.0833
p.L62F	TCGA-KQ-A41N	BLCA	TCGA	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.2222
p.L62F	DO223588	BLCA	ICGC	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.2222
p.N63D	TCGA-SX-A7SN	KIRP	TCGA	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.25
p.N63D	TCGA-VQ-A8P2	STAD	TCGA	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.25
p.N63D	DO49786	KIRP	ICGC	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.25
p.N63D	DO51761	STAD	ICGC	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.25
p.Y72C	DO225388	BRCA	ICGC	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.2222
p.R68Q	DO222952	BTCA	ICGC	DYR	CBL_MET	66:68	Mutation altering degron motif	0.7329
p.D74Y	DO50713	ORCA	ICGC	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.1667
p.R70Q	ACH-001063	Ovarian Cancer	CCLE	DYR	CBL_MET	66:68	Mutation rewiring degron network	0.2778

Kaplan plot for CLK4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLK4

UniProt ID: Q9HAZ1

Entrez ID: 57396

Protein name: Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLK4 in