DegronMD - Q9HB58(SP110)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C152F	TCGA-55-8506	LUAD	TCGA	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1389
p.C152F	DO45390	LUAD	ICGC	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1389
p.S157N	TCGA-E2-A1IN	BRCA	TCGA	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation blocking phosphorylation signal	0.7222
p.S157N	DO3134	BRCA	ICGC	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation blocking phosphorylation signal	0.7222
p.S150L	TCGA-ER-A19F	SKCM	TCGA	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation blocking phosphorylation signal	0.5278
p.S150L	DO37679	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation blocking phosphorylation signal	0.5278
p.S173L	DO222798	COCA	ICGC	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation blocking phosphorylation signal	0.5
p.S173L	ACH-001484	Leukemia	CCLE	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation blocking phosphorylation signal	0.5
p.S173L	ACH-001485	Leukemia	CCLE	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation blocking phosphorylation signal	0.5
p.R150Q	DO50401	ESAD	ICGC	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation blocking phosphorylation signal	0.5278
p.A153V	DO234219	ESAD	ICGC	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1667
p.G160V	DO233202	GACA	ICGC	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation altering degron motif	0.6421
p.P167T	DO11848	GBM	ICGC	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2222
p.C170F	DO52161	PAEN	ICGC	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1389
p.P154L	DO47100	RECA	ICGC	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.1944
p.P167H	DO37695	SKCM	ICGC	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.2222
p.H149R	DO51783	STAD	ICGC	PGTSS	DEG_SPOP_SBC_1	159:163	Mutation rewiring degron network	0.0556

Kaplan plot for SP110 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SP110

UniProt ID: Q9HB58

Entrez ID: 3431

Protein name: Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SP110 in