DegronMD - Q9HCC9(ZFYVE28)

ZFYVE28

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R485Q	TCGA-A5-A1OF	UCEC	TCGA	AGTSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1389
p.S477I	TCGA-BR-6852	STAD	TCGA	AGTSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7341
p.S477I	DO38202	STAD	ICGC	AGTSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7341
p.G485E	DO230336	COCA	ICGC	AGTSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1389
p.A486D	DO233255	GACA	ICGC	AGTSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1111
p.Q464K	DO228948	LICA	ICGC	AGTSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.0556
p.L486M	DO232761	PBCA	ICGC	AGTSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1111
p.S468L	DO37567	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1667
p.S468L	TE-4	oesophagus	COSMIC	AGTSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1667
p.S468L	SNU-61	large intestine	COSMIC	AGTSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1667
p.P470L	DO47305	SKCM	ICGC	AGTSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.2222
p.R485W	SIDM00431	T-Lymphoblastic Leukemia	GDSC	AGTSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1389
p.R485W	ACH-000918	Leukemia	CCLE	AGTSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1389
p.R485W	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	AGTSS	DEG_SPOP_SBC_1	474:478	Mutation rewiring degron network	0.1389
p.G477D	CAL-62	thyroid	COSMIC	AGTSS	DEG_SPOP_SBC_1	474:478	Mutation altering degron motif	0.7198

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*NOTE: the Kaplan plots were collected from OncoLnc