DegronMD - Q9HCG8(CWC22)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S669F	TCGA-4Z-AA7M	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	668:672	Mutation altering degron motif	0.6871
p.S669F	DO218976	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	668:672	Mutation altering degron motif	0.6871
p.E662Q	TCGA-AC-A23H	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.1667
p.E662Q	DO2401	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.1667
p.S687F	TCGA-DF-A2KU	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	674:678	Mutation rewiring degron network	0.0833
p.S687F	DO223286	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	674:678	Mutation rewiring degron network	0.0833
p.S670C	DO1071	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	668:672	Mutation altering degron motif	0.7541
p.A674V	DO233179	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	674:678	Mutation altering degron motif	0.5825
p.P668Q	DO229031	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	668:672	Mutation altering degron motif	0.7035
p.Q663K	DO229041	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.1944
p.S666F	DO222837	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.2778
p.S666F	DO222837	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	674:678	Mutation rewiring degron network	0.1111
p.D684N	SIDM00194	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	674:678	Mutation rewiring degron network	0.1667
p.D684N	SIDM00465	Ovarian Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	674:678	Mutation rewiring degron network	0.1667
p.D684N	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	674:678	Mutation rewiring degron network	0.1667
p.S671F	SIDM00007	Other Solid Cancers	GDSC	PSSSS	DEG_SPOP_SBC_1	668:672	Mutation altering degron motif	0.7982
p.S671F	ACH-001550	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	668:672	Mutation altering degron motif	0.7982
p.S671F	MCC13	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	668:672	Mutation altering degron motif	0.7982
p.S685C	SIDM00779	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	674:678	Mutation rewiring degron network	0.1389
p.S685C	ACH-000491	Colon/Colorectal Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	674:678	Mutation rewiring degron network	0.1389
p.S685C	NCI-H716	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	674:678	Mutation rewiring degron network	0.1389
p.S670A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	668:672	Mutation altering degron motif	0.7588
p.S670A	DND-41	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	668:672	Mutation altering degron motif	0.7588

Kaplan plot for CWC22 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CWC22

UniProt ID: Q9HCG8

Entrez ID: 57703

Protein name: Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CWC22 in