DegronMD - Q9NPJ6(MED4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A3T	TCGA-06-5408	GBM	TCGA	AASSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.6028
p.A3T	DO12862	GBM	ICGC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.6028
p.K11N	TCGA-EE-A2GD	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	2:6	Mutation substituting flanking lysine	0.3056
p.K11N	DO37603	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation substituting flanking lysine	0.3056
p.G15R	TCGA-EE-A2MS	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0833
p.G15R	DO37567	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.0833
p.G7S	TCGA-VQ-A94R	STAD	TCGA	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.3056
p.G7S	DO222372	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.3056
p.A2G	DO225118	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.754
p.A2G	DO227860	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.754
p.E12Q	SIDM01043	Other Sarcomas	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM01109	Other Sarcomas	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00025	Head and Neck Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00185	Melanoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00042	Pancreatic Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00057	Neuroblastoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00472	Ovarian Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00832	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00820	Kidney Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00637	B-Cell Non-Hodgkin's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00905	Cervical Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00105	Ovarian Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM01650	Non-Cancerous	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00006	Other Solid Cancers	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00882	Breast Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00918	Ovarian Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00039	Ovarian Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00839	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00209	Glioblastoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM01624	Bladder Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM01529	Bladder Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM00093	Ovarian Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.E12Q	SIDM01325	Pancreatic Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1667
p.K11R	SIDM00324	Neuroblastoma	GDSC	AASSS	DEG_SPOP_SBC_1	2:6	Mutation substituting flanking lysine	0.3056
p.K11R	ACH-001674	Neuroblastoma	CCLE	AASSS	DEG_SPOP_SBC_1	2:6	Mutation substituting flanking lysine	0.3056

Kaplan plot for MED4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MED4

UniProt ID: Q9NPJ6

Entrez ID: 29079

Protein name: Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MED4 in