DegronMD - Q9NR46(SH3GLB2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A292T	TCGA-EI-6882	READ	TCGA	PLSST	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.25
p.A297T	DO222454	BTCA	ICGC	PLSST	DEG_SPOP_SBC_1	295:299	Mutation altering degron motif	0.7139
p.A297T	DO36531	READ	ICGC	PLSST	DEG_SPOP_SBC_1	295:299	Mutation altering degron motif	0.7139
p.G292D	DO222905	BTCA	ICGC	PLSST	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.25
p.T308N	DO228976	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.0833
p.G287S	SIDM00516	Melanoma	GDSC	PLSST	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1111
p.G287S	MZ7-mel	skin	COSMIC	PLSST	DEG_SPOP_SBC_1	295:299	Mutation rewiring degron network	0.1111
p.S297I	ACH-000989	Colon/Colorectal Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	295:299	Mutation altering degron motif	0.7341
p.L296P	ACH-001518	Endometrial/Uterine Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	295:299	Mutation altering degron motif	0.6471

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons