DegronMD - Q9NR56(MBNL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A364S	TCGA-66-2742	LUSC	TCGA	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1111
p.A364S	DO228974	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1111
p.A364S	DO26439	LUSC	ICGC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1111
p.A352T	TCGA-FI-A2D0	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.7139
p.A352T	DO43891	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.7139
p.A352T	SIDM00839	Colorectal Carcinoma	GDSC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.7139
p.A352T	LoVo	large intestine	COSMIC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.7139
p.S356F	DO52582	BOCA	ICGC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.7982
p.A363T	DO222798	COCA	ICGC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1389
p.A363T	DO233884	GACA	ICGC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1389
p.A363T	SIDM00217	Colorectal Carcinoma	GDSC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1389
p.A363T	SNU-1040	large intestine	COSMIC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1389
p.G344C	DO228900	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1111
p.A352S	DO229041	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.7588
p.P361L	DO220876	MELA	ICGC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1944
p.A346T	ACH-000950	Colon/Colorectal Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1667
p.A346T	LoVo	large intestine	COSMIC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1667
p.A357T	ACH-000999	Colon/Colorectal Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.3056
p.A357T	SNU-1040	large intestine	COSMIC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.3056
p.A358T	ACH-001862	Bile Duct Cancer	CCLE	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.2778
p.P352S	COLO-679	skin	COSMIC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation altering degron motif	0.6752
p.Q342H	MOG-G-UVW	central nervous system	COSMIC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.0556
p.A345T	SNU-1040	large intestine	COSMIC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1389
p.A358V	639-V	urinary tract	COSMIC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.2778
p.A364T	LoVo	large intestine	COSMIC	AATTS	DEG_SPOP_SBC_1	352:356	Mutation rewiring degron network	0.1111

Kaplan plot for MBNL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MBNL1

UniProt ID: Q9NR56

Entrez ID: 4154

Protein name: Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MBNL1 in