DegronMD - Q9NR64(KLHL1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T67I	TCGA-34-5232	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.1944
p.T67I	DO27168	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.1944
p.P82R	TCGA-44-7667	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.7512
p.P82R	DO23830	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.7512
p.R62S	TCGA-49-AARN	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.0556
p.R62S	DO218923	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.0556
p.W69C	TCGA-55-7725	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.25
p.W69C	DO24636	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.25
p.S73Y	TCGA-55-8614	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation altering degron motif	0.6009
p.S73Y	DO48885	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation altering degron motif	0.6009
p.S66R	TCGA-86-7714	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.1667
p.S66R	DO24870	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.1667
p.G64S	TCGA-94-8490	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.1111
p.G64S	DO52021	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.1111
p.S75T	TCGA-99-8032	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation altering degron motif	0.7116
p.S75T	DO23765	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation altering degron motif	0.7116
p.S79L	TCGA-AA-3982	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.25
p.S79L	TCGA-AA-3982	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.R62I	TCGA-AP-A1E0	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.0556
p.R62I	DO228939	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.0556
p.R62I	DO43154	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.0556
p.P82L	TCGA-C5-A1M9	CESC	TCGA	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.7582
p.S74P	TCGA-DU-6392	LGG	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation altering degron motif	0.6752
p.S74P	DO22237	LGG	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation altering degron motif	0.6752
p.N93D	TCGA-E6-A2P8	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1389
p.N93D	DO40924	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1389
p.K70N	TCGA-EO-A3AY	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.2778
p.K70N	TCGA-F5-6814	READ	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.2778
p.K70N	DO36556	READ	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.2778
p.K70N	DO43202	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.2778
p.S76C	TCGA-GC-A4ZW	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation altering degron motif	0.8652
p.S66I	TCGA-IB-7651	PAAD	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.1667
p.S66I	DO46657	PAAD	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.1667
p.K71M	TCGA-IC-A6RF	ESCA	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.3056
p.S87Y	TCGA-SG-A6Z4	SARC	TCGA	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.3056
p.S87Y	DO220267	SARC	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.3056
p.K70E	TCGA-WE-A8K4	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.2778
p.K70E	DO51281	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.2778
p.L70F	DO49964	CESC	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.2778
p.D72E	DO222548	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation altering degron motif	0.6758
p.N68I	DO14710	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.2222
p.A69V	DO14212	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.25
p.S74F	DO228902	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation altering degron motif	0.7982
p.A95E	DO228952	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0833
p.P72H	DO229033	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation altering degron motif	0.7694
p.P67H	DO23324	LINC	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.1944
p.P67H	DO37961	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.1944
p.A77S	DO25797	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation blocking phosphorylation signal	0.75
p.A77S	DO25797	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation blocking phosphorylation signal	0.6389
p.L82F	DO25320	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.6981
p.T79A	DO25396	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.25
p.T79A	DO25396	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.L92I	DO45335	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1667
p.E86D	DO230942	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.6758
p.E86D	DO224589	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.6758
p.E83K	DO223718	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.7022
p.W71L	DO36459	READ	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.3056
p.D87N	DO37856	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.3056
p.E90K	DO37406	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.2222
p.G80C	DO47407	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.2222
p.G80C	DO47407	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.2778
p.D66Y	DO51761	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.1667
p.D66Y	DO43186	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.1667
p.A96V	DO48020	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0556
p.A96V	DO41199	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0556
p.G80D	DO229211	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.2222
p.G80D	DO229211	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.2778
p.E90D	DO50075	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.2222
p.E90D	DO41758	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.2222
p.M62L	DO42280	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	72:76	Mutation rewiring degron network	0.0556
p.L96M	SIDM01284	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0556
p.T95A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0833
p.T95A	ACH-000937	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0833
p.T95A	PF-382	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0833
p.N93S	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1389
p.N93S	ACH-000937	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1389
p.N93S	PF-382	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KLHL1

UniProt ID: Q9NR64

Entrez ID: 57626

Protein name: Kelch-like protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KLHL1 in