DegronMD - Q9NRL3(STRN4)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P580L	TCGA-CK-4951	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.25
p.P573L	DO10582	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.7582
p.P573L	DO220912	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.7582
p.V568I	DO233731	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1944
p.T583S	DO228278	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1667
p.S577N	ACH-000994	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	573:577	Mutation altering degron motif	0.7069
p.P578R	ACH-000995	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.3056
p.R585C	SW962	vulva	COSMIC	PSSSS	DEG_SPOP_SBC_1	573:577	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons