DegronMD - Q9NRR2(TPSG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R180W	TCGA-77-6842	LUSC	TCGA	PPPY	ITCH	174:177	Mutation rewiring degron network	0.25
p.R180W	DO27413	LUSC	ICGC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.25
p.G170E	TCGA-D3-A51G	SKCM	TCGA	PPPY	ITCH	174:177	Mutation rewiring degron network	0.2222
p.G170E	DO47700	SKCM	ICGC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.2222
p.S178C	TCGA-WE-AAA0	SKCM	TCGA	PPPY	ITCH	174:177	Mutation rewiring degron network	0.3056
p.S178C	DO51294	SKCM	ICGC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.3056
p.R168W	DO222955	BTCA	ICGC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.1667
p.V186M	DO233281	GACA	ICGC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.0833
p.E171Q	DO50931	LICA	ICGC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.25
p.P176S	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	174:177	Mutation altering degron motif	0.5641
p.P176S	NCI-H1651	lung	COSMIC	PPPY	ITCH	174:177	Mutation altering degron motif	0.5641
p.R180Q	SIDM00995	Other Solid Cancers	GDSC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.25
p.E169K	SIDM00893	Breast Carcinoma	GDSC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.1944
p.E169K	ACH-000536	Breast Cancer	CCLE	PPPY	ITCH	174:177	Mutation rewiring degron network	0.1944
p.E169K	BT-20	breast	COSMIC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.1944
p.G165S	SIDM00907	Burkitt's Lymphoma	GDSC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.0833
p.G165S	ACH-000440	Lymphoma	CCLE	PPPY	ITCH	174:177	Mutation rewiring degron network	0.0833
p.G165S	CA46	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	174:177	Mutation rewiring degron network	0.0833
p.P175L	SIDM00125	Kidney Carcinoma	GDSC	PPPY	ITCH	174:177	Mutation altering degron motif	0.7582
p.P176L	SIDM00479	Esophageal Carcinoma	GDSC	PPPY	ITCH	174:177	Mutation altering degron motif	0.6471

Kaplan plot for TPSG1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TPSG1

UniProt ID: Q9NRR2

Entrez ID: 25823

Protein name: Tryptase gamma (EC 3.4.21.-) (Serine protease 31) (Transmembrane tryptase) [Cleaved into: Tryptase gamma light chain; Tryptase gamma heavy chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TPSG1 in