PLSCR3
UniProt ID: Q9NRY6
Entrez ID: 57048
Protein name: Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:29337693, PubMed:31769662)....
FUNCTION: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:29337693, PubMed:31769662). Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:12649167). Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (PubMed:14573790, PubMed:17226776, PubMed:18358005). Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (PubMed:18491232). Regulates cardiolipin de novo biosynthesis and its resynthesis (PubMed:16939411). {ECO:0000269|PubMed:12649167, ECO:0000269|PubMed:14573790, ECO:0000269|PubMed:16939411, ECO:0000269|PubMed:17226776, ECO:0000269|PubMed:18358005, ECO:0000269|PubMed:18491232, ECO:0000269|PubMed:29337693, ECO:0000269|PubMed:31769662}.
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GO - Biological processes (BP):
apoptotic process [GO:0006915]; cardiolipin biosynthetic process [GO:0032049]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol homeostasis [GO:0042632]; glucose homeostasis [GO:0042593]; plasma membrane phospholipid scrambling [GO:0017121]; regulation of apoptotic process [GO:00429...
apoptotic process [GO:0006915]; cardiolipin biosynthetic process [GO:0032049]; cellular response to lipopolysaccharide [GO:0071222]; cholesterol homeostasis [GO:0042632]; glucose homeostasis [GO:0042593]; plasma membrane phospholipid scrambling [GO:0017121]; regulation of apoptotic process [GO:0042981]; regulation of release of cytochrome c from mitochondria [GO:0090199]
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GO - Molecular function (MF):
calcium-dependent protein binding [GO:0048306]; calcium ion binding [GO:0005509]; lead ion binding [GO:0032791]; magnesium ion binding [GO:0000287]; mercury ion binding [GO:0045340]; phospholipid scramblase activity [GO:0017128]; protein self-association [GO:0043621]; SH3 domain binding [GO:0017124]...
calcium-dependent protein binding [GO:0048306]; calcium ion binding [GO:0005509]; lead ion binding [GO:0032791]; magnesium ion binding [GO:0000287]; mercury ion binding [GO:0045340]; phospholipid scramblase activity [GO:0017128]; protein self-association [GO:0043621]; SH3 domain binding [GO:0017124]
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GO - Cellular component (CC):
cytosol [GO:0005829]; integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]...
cytosol [GO:0005829]; integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]
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PLSCR3
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Kaplan plot for PLSCR3 in
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*NOTE: the Kaplan plots were collected from OncoLnc