DegronMD - Q9NS40(KCNH7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1065A	TCGA-A5-A0G2	UCEC	TCGA	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.25
p.T1065A	DO41235	UCEC	ICGC	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.25
p.V1074I	TCGA-AJ-A3EL	UCEC	TCGA	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.25
p.V1074I	DO41542	UCEC	ICGC	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.25
p.Y1071C	TCGA-CG-5721	STAD	TCGA	PPAY	ITCH	1068:1071	Mutation altering degron motif	0.7087
p.Y1071C	DO38192	STAD	ICGC	PPAY	ITCH	1068:1071	Mutation altering degron motif	0.7087
p.V1074L	TCGA-D7-6520	STAD	TCGA	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.25
p.V1074L	DO38643	STAD	ICGC	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.25
p.T1064I	TCGA-F4-6570	COAD	TCGA	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.2222
p.T1064I	DO10443	COAD	ICGC	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.2222
p.M1073I	TCGA-FS-A1ZQ	SKCM	TCGA	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.2778
p.M1073I	DO37442	SKCM	ICGC	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.2778
p.T1075K	DO228976	LICA	ICGC	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.2222
p.Q1058K	DO229018	LICA	ICGC	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.0556
p.P1068T	DO45133	LIRI	ICGC	PPAY	ITCH	1068:1071	Mutation altering degron motif	0.7031
p.Q1058E	DO229543	UTCA	ICGC	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.0556
p.M1073T	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.2778
p.M1073T	ACH-002301	Lymphoma	CCLE	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.2778
p.M1073T	RF-48	stomach	COSMIC	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.2778
p.V1074A	SIDM00217	Colorectal Carcinoma	GDSC	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.25
p.V1074A	ACH-000999	Colon/Colorectal Cancer	CCLE	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.25
p.V1074A	SNU-1040	large intestine	COSMIC	PPAY	ITCH	1068:1071	Mutation rewiring degron network	0.25
p.P1068H	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	1068:1071	Mutation altering degron motif	0.7694
p.P1068H	ACH-002337	Lung Cancer	CCLE	PPAY	ITCH	1068:1071	Mutation altering degron motif	0.7694

Kaplan plot for KCNH7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNH7

UniProt ID: Q9NS40

Entrez ID: 90134

Protein name: Potassium voltage-gated channel subfamily H member 7 (Ether-a-go-go-related gene potassium channel 3) (ERG-3) (Eag-related protein 3) (Ether-a-go-go-related protein 3) (hERG-3) (Voltage-gated potassium channel subunit Kv11.3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNH7 in