DegronMD - Q9NT68(TENM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S182P	DO891	BOCA	ICGC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.1667
p.P177S	DO233878	GACA	ICGC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.3056
p.P177S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.3056
p.P177S	DND-41	haematopoietic and lymphoid tissue	COSMIC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.3056
p.S175F	DO220851	MELA	ICGC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation altering degron motif	0.7982
p.R169C	DO220886	MELA	ICGC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.25
p.R169C	DO229462	SKCA	ICGC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.25
p.R169C	DO37861	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.25
p.D165N	DO37782	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.1389
p.G168S	DO37409	SKCM	ICGC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.2222
p.G168R	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.2222
p.A186V	SIDM00140	Melanoma	GDSC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.0556
p.A186V	ACH-000968	Skin Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.0556
p.A186V	COLO-792	skin	COSMIC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.0556
p.S167Y	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.1944
p.S167Y	ACH-000451	Lung Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.1944
p.S167Y	NCI-H2085	lung	COSMIC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.1944
p.R169L	ACH-000563	Lung Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.25
p.R169L	EBC-1	lung	COSMIC	PPTSS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.25

Kaplan plot for TENM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TENM2

UniProt ID: Q9NT68

Entrez ID: 57451

Protein name: Teneurin-2 (Ten-2) (Protein Odd Oz/ten-m homolog 2) (Tenascin-M2) (Ten-m2) (Teneurin transmembrane protein 2) [Cleaved into: Ten-2, soluble form; Ten-2 intracellular domain (Ten-2 ICD)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TENM2 in