DegronMD - Q9NUT2(ABCB8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G112E	TCGA-04-1331	OV	TCGA	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.G112E	DO28119	OV	ICGC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.F123S	TCGA-44-7662	LUAD	TCGA	PASST	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7982
p.F123S	DO23597	LUAD	ICGC	PASST	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.7982
p.V130F	TCGA-DY-A1DD	READ	TCGA	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1667
p.V130F	DO36546	READ	ICGC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1667
p.G112W	TCGA-EE-A2M8	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.G112W	DO38075	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.F123L	TCGA-EO-A22R	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.6981
p.F123L	DO42713	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	120:124	Mutation altering degron motif	0.6981
p.G132W	TCGA-FS-A1ZP	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.G132W	DO37703	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.G112A	TCGA-GU-A767	BLCA	TCGA	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.G112A	DO51892	BLCA	ICGC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.V114A	DO227987	COCA	ICGC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1667
p.S129F	DO219174	LUSC	ICGC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1944
p.R132Q	DO50686	ORCA	ICGC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.1111
p.D134E	DO50727	ORCA	ICGC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0556
p.V111M	DO224705	PACA	ICGC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.0833
p.A125S	DO229234	THCA	ICGC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.3056
p.R117H	DO219774	UCEC	ICGC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.25
p.H126N	SIDM01006	Plasma Cell Myeloma	GDSC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.2778
p.H126N	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.2778
p.P119S	SIDM00426	Rhabdomyosarcoma	GDSC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.3056
p.P119S	SIDM01055	Glioblastoma	GDSC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.3056
p.P119S	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.3056
p.P126H	ACH-002299	Leukemia	CCLE	PASST	DEG_SPOP_SBC_1	120:124	Mutation rewiring degron network	0.2778

Kaplan plot for ABCB8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABCB8

UniProt ID: Q9NUT2

Entrez ID: 11194

Protein name: Mitochondrial potassium channel ATP-binding subunit (ATP-binding cassette sub-family B member 8, mitochondrial) (ABCB8) (Mitochondrial ATP-binding cassette 1) (M-ABC1) (Mitochondrial sulfonylurea-receptor) (MITOSUR)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABCB8 in