DegronMD - Q9NUW8(TDP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S32F	TCGA-05-4397	LUAD	TCGA	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7982
p.S32F	DO25320	LUAD	ICGC	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7982
p.L33I	TCGA-A5-A0G1	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.3056
p.L33I	DO42472	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.3056
p.E21Q	TCGA-CD-8529	STAD	TCGA	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1389
p.E21Q	DO47753	STAD	ICGC	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1389
p.E20G	TCGA-DI-A1BU	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1111
p.E20G	DO42023	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1111
p.S31Y	TCGA-EB-A24D	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.712
p.S31Y	DO37440	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.712
p.T30I	TCGA-VQ-A8P2	STAD	TCGA	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7078
p.T30I	DO51761	STAD	ICGC	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7078
p.S23F	DO566	BLCA	ICGC	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1944
p.S18N	DO228963	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation blocking phosphorylation signal	0.5
p.A40S	DO229036	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1111
p.A24V	DO51540	PACA	ICGC	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation substituting flanking lysine	0.3333
p.T18M	DO228764	PRAD	ICGC	PSTSS	DEG_SPOP_SBC_1	28:32	Mutation blocking phosphorylation signal	0.5

Kaplan plot for TDP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TDP1

UniProt ID: Q9NUW8

Entrez ID: 55775

Protein name: Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TDP1 in