DegronMD - Q9NV35(NUDT15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S83Y	TCGA-AA-3984	COAD	TCGA	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.25
p.S83Y	TCGA-AG-A002	READ	TCGA	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.25
p.S83Y	TCGA-AP-A056	UCEC	TCGA	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.25
p.S83Y	TCGA-EI-6917	READ	TCGA	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.25
p.S83Y	TCGA-EY-A1G8	UCEC	TCGA	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.25
p.S83Y	DO9002	COAD	ICGC	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.25
p.S83Y	DO36881	READ	ICGC	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.25
p.S83Y	DO43578	UCEC	ICGC	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.25
p.S83Y	DO43971	UCEC	ICGC	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.25
p.Y92D	TCGA-CA-6718	COAD	TCGA	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.2778
p.Y92D	DO7801	COAD	ICGC	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.2778
p.M97I	TCGA-FI-A2EW	UCEC	TCGA	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.1389
p.M97I	DO41500	UCEC	ICGC	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.1389
p.E86K	DO48396	BLCA	ICGC	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation altering degron motif	0.591
p.V81L	DO229026	LICA	ICGC	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.1944
p.A78S	DO229031	LICA	ICGC	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation rewiring degron network	0.1111
p.T94I	DO230453	UTCA	ICGC	EKENY	DEG_APCC_KENBOX_2	86:90	Mutation blocking phosphorylation signal	0.6667

Kaplan plot for NUDT15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUDT15

UniProt ID: Q9NV35

Entrez ID: 55270

Protein name: Nucleotide triphosphate diphosphatase NUDT15 (EC 3.6.1.9) (MutT homolog 2) (MTH2) (Nucleoside diphosphate-linked moiety X motif 15) (Nudix motif 15) (Nucleoside diphosphate-linked to another moiety X hydrolase 15) (Nudix hydrolase 15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUDT15 in