DegronMD - Q9NVE5(USP40)

USP40

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K847I	TCGA-DD-AAD2	LIHC	TCGA	APSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1389
p.K847I	DO52219	LIHC	ICGC	APSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1389
p.M837R	TCGA-E6-A1LX	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	836:840	Mutation altering degron motif	0.8632
p.M837R	DO41020	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	836:840	Mutation altering degron motif	0.8632
p.L845F	TCGA-FD-A43X	BLCA	TCGA	APSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1944
p.L845F	DO44067	BLCA	ICGC	APSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1944
p.G846E	DO233203	GACA	ICGC	APSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1667
p.P849Q	DO228974	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.0833
p.T829N	DO229026	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1389
p.D826E	DO229041	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.0556
p.S827C	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	836:840	Mutation blocking phosphorylation signal	0.5278
p.S827C	NCI-H2172	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	836:840	Mutation blocking phosphorylation signal	0.5278
p.L829F	ACH-001369	Ovarian Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc