DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
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EVA1B
UniProt ID:
Q9NVM1
Entrez ID:
55194
Protein name:
Protein eva-1 homolog B (Protein FAM176B)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
integral component of membrane [GO:0016021]...
integral component of membrane [GO:0016021]
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
EVA1B
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.R58W
DO227802
COCA
ICGC
PRSST
DEG_SPOP_SBC_1
68:72
Mutation rewiring degron network
0.0556
p.P59T
DO50715
ORCA
ICGC
PRSST
DEG_SPOP_SBC_1
68:72
Mutation rewiring degron network
0.0833
p.A63T
DO229250
THCA
ICGC
PRSST
DEG_SPOP_SBC_1
68:72
Mutation rewiring degron network
0.1944
p.R60Q
ACH-000158
Lymphoma
CCLE
PRSST
DEG_SPOP_SBC_1
68:72
Mutation rewiring degron network
0.1111
p.P62L
ACH-000932
Gastric Cancer
CCLE
PRSST
DEG_SPOP_SBC_1
68:72
Mutation rewiring degron network
0.1667
p.P62L
NCI-SNU-1
stomach
COSMIC
PRSST
DEG_SPOP_SBC_1
68:72
Mutation rewiring degron network
0.1667
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for EVA1B in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc