DegronMD - Q9NX45(SOHLH2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R330Q	TCGA-32-5222	GBM	TCGA	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.2222
p.R330Q	TCGA-EO-A22R	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.2222
p.R330Q	DO12832	GBM	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.2222
p.R330Q	DO42713	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.2222
p.E343K	TCGA-AA-3977	COAD	TCGA	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1944
p.E343K	TCGA-BS-A0UV	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1944
p.E343K	DO8730	COAD	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1944
p.E343K	DO42793	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1944
p.I333T	TCGA-AF-A56K	READ	TCGA	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.3056
p.I333T	DO50275	READ	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.3056
p.K327N	TCGA-AX-A0J0	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.K327N	TCGA-D1-A174	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.K327N	DO40900	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.K327N	DO41133	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.P335A	TCGA-CR-7399	HNSC	TCGA	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.6392
p.P335A	DO15759	HNSC	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.6392
p.M338I	TCGA-D8-A1XK	BRCA	TCGA	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.7618
p.M338I	DO4749	BRCA	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.7618
p.A336V	TCGA-EE-A2GN	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.6936
p.A336V	DO37896	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.6936
p.S334F	TCGA-EE-A2MJ	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.7982
p.S334F	DO38099	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.7982
p.A339V	DO233864	GACA	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.3056
p.A344E	DO229019	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1667
p.A339S	DO50830	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.3056
p.V337I	DO33105	PACA	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.7076
p.V337I	DO49457	PACA	ICGC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.7076
p.S340L	Hs940-T	skin	COSMIC	VPSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.2778

Kaplan plot for SOHLH2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOHLH2

UniProt ID: Q9NX45

Entrez ID: 100526761

Protein name: Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOHLH2 in