DegronMD - Q9NXE4(SMPD4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G250R	TCGA-60-2709	LUSC	TCGA	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2778
p.G250R	TCGA-HU-A4GT	STAD	TCGA	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2778
p.G250R	SIDM01617	Endometrial Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2778
p.G250R	ACH-000994	Endometrial/Uterine Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2778
p.E244Q	DO49784	BLCA	ICGC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.6744
p.S256R	DO229027	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1111
p.A250T	DO22920	LIHC	ICGC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2778
p.A236S	DO26761	LUSC	ICGC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1111
p.A251V	DO43098	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.25
p.A238T	DO43779	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1667
p.S253N	SIDM00499	Prostate Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1944
p.S253N	ACH-000956	Prostate Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1944
p.S253N	22RV1	prostate	COSMIC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1944
p.P256L	SIDM00108	Melanoma	GDSC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1111
p.P256L	SIDM00504	Glioma	GDSC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1111
p.P256L	SIDM00312	Plasma Cell Myeloma	GDSC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1111
p.G250W	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2778
p.G250W	ACH-000929	Lung Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2778
p.G250W	NCI-H2110	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.2778
p.S248N	SIDM00217	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7069
p.S248N	ACH-000999	Colon/Colorectal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7069
p.S248N	SNU-1040	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7069
p.P244L	ACH-001518	Endometrial/Uterine Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7582
p.K254E	MC-1010	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation rewiring degron network	0.1667
p.M248I	GP5d	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	244:248	Mutation altering degron motif	0.7618

Kaplan plot for SMPD4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMPD4

UniProt ID: Q9NXE4

Entrez ID: 55627

Protein name: Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMPD4 in