DegronMD - Q9NYA4(MTMR4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1014F	TCGA-A5-A1OF	UCEC	TCGA	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.1667
p.T1018M	TCGA-AP-A059	UCEC	TCGA	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.0556
p.T1018M	TCGA-BS-A0V4	UCEC	TCGA	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.0556
p.T1018M	TCGA-EI-7004	READ	TCGA	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.0556
p.P1005S	TCGA-AX-A0J1	UCEC	TCGA	PPLY	ITCH	1005:1008	Mutation altering degron motif	0.6752
p.V996I	TCGA-AX-A3FS	UCEC	TCGA	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.0833
p.D1010N	TCGA-DZ-6132	KIRP	TCGA	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.2778
p.Y1008H	TCGA-G4-6588	COAD	TCGA	PPLY	ITCH	1005:1008	Mutation altering degron motif	0.7229
p.T1018R	TCGA-WE-AAA0	SKCM	TCGA	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.0556
p.L1016F	DO1128	BRCA	ICGC	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.1111
p.E1004Q	DO14830	HNSC	ICGC	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.3056
p.I995N	DO45422	LUAD	ICGC	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.0556
p.H997P	DO27996	OV	ICGC	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.1111
p.P1001S	DO227919	PBCA	ICGC	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.2222
p.K1017N	DO51795	STAD	ICGC	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.0833
p.L998P	SIDM00193	Colorectal Carcinoma	GDSC	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.1389
p.L998P	ACH-000991	Colon/Colorectal Cancer	CCLE	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.1389
p.L998P	SNU-81	large intestine	COSMIC	PPLY	ITCH	1005:1008	Mutation rewiring degron network	0.1389

Kaplan plot for MTMR4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTMR4

UniProt ID: Q9NYA4

Entrez ID: 9110

Protein name: Myotubularin-related protein 4 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Zinc finger FYVE domain-containing protein 11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTMR4 in