DegronMD - Q9NYF0(DACT1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A667G	TCGA-56-7582	LUSC	TCGA	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.1111
p.A683D	TCGA-BP-5186	KIRC	TCGA	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.1667
p.R677W	TCGA-CD-A4MG	STAD	TCGA	DYR	CBL_MET	675:677	Mutation altering degron motif	0.8634
p.R677W	TCGA-EE-A2GN	SKCM	TCGA	DYR	CBL_MET	675:677	Mutation altering degron motif	0.8634
p.E684K	TCGA-CV-7568	HNSC	TCGA	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.1389
p.A670T	DO451	BLCA	ICGC	DYR	CBL_MET	675:677	Mutation substituting flanking lysine	0.3056
p.A670T	DO43899	UCEC	ICGC	DYR	CBL_MET	675:677	Mutation substituting flanking lysine	0.3056
p.A670T	DO42592	UCEC	ICGC	DYR	CBL_MET	675:677	Mutation substituting flanking lysine	0.3056
p.A670T	ACH-000728	Leukemia	CCLE	DYR	CBL_MET	675:677	Mutation substituting flanking lysine	0.3056
p.Y676C	DO51592	CESC	ICGC	DYR	CBL_MET	675:677	Mutation altering degron motif	0.7087
p.A681T	DO8447	COAD	ICGC	DYR	CBL_MET	675:677	Mutation blocking phosphorylation signal	0.6667
p.A681T	DO42384	UCEC	ICGC	DYR	CBL_MET	675:677	Mutation blocking phosphorylation signal	0.6667
p.A670V	DO233121	GACA	ICGC	DYR	CBL_MET	675:677	Mutation substituting flanking lysine	0.3056
p.A670V	DO23214	LINC	ICGC	DYR	CBL_MET	675:677	Mutation substituting flanking lysine	0.3056
p.A670V	DO51666	PAAD	ICGC	DYR	CBL_MET	675:677	Mutation substituting flanking lysine	0.3056
p.A670V	DO40918	UCEC	ICGC	DYR	CBL_MET	675:677	Mutation substituting flanking lysine	0.3056
p.A670V	DO52409	UCEC	ICGC	DYR	CBL_MET	675:677	Mutation substituting flanking lysine	0.3056
p.A677T	DO228972	LICA	ICGC	DYR	CBL_MET	675:677	Mutation altering degron motif	0.7139
p.A677T	DO51776	STAD	ICGC	DYR	CBL_MET	675:677	Mutation altering degron motif	0.7139
p.A677T	DO52412	UCEC	ICGC	DYR	CBL_MET	675:677	Mutation altering degron motif	0.7139
p.A677S	DO26414	LUAD	ICGC	DYR	CBL_MET	675:677	Mutation altering degron motif	0.7588
p.G666R	DO23693	LUAD	ICGC	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.0833
p.A684G	DO223721	LUSC	ICGC	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.1389
p.D686N	DO50690	ORCA	ICGC	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.0833
p.S678T	DO47132	RECA	ICGC	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.3056
p.S687F	DO47700	SKCM	ICGC	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.0556
p.G666V	DO47613	SKCM	ICGC	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.0833
p.V683M	DO42600	UCEC	ICGC	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.1667
p.A681V	DO41518	UCEC	ICGC	DYR	CBL_MET	675:677	Mutation blocking phosphorylation signal	0.6667
p.R673Q	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.2778
p.A667T	SIDM00282	Colorectal Carcinoma	GDSC	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.1111
p.G666E	ACH-000220	Lymphoma	CCLE	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.0833
p.P673L	ACH-000308	Ovarian Cancer	CCLE	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.2778
p.P673L	EFO-21	ovary	COSMIC	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.2778
p.P669S	ACH-000325	Gastric Cancer	CCLE	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.1667
p.S678N	ACH-000987	Skin Cancer	CCLE	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.3056
p.S678N	Mewo	skin	COSMIC	DYR	CBL_MET	675:677	Mutation rewiring degron network	0.3056
p.Y668N	ACH-001802	Liposarcoma	CCLE	DYR	CBL_MET	675:677	Mutation substituting flanking lysine	0.25

Kaplan plot for DACT1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DACT1

UniProt ID: Q9NYF0

Entrez ID: 51339

Protein name: Dapper homolog 1 (hDPR1) (Dapper antagonist of catenin 1) (Hepatocellular carcinoma novel gene 3 protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DACT1 in