DegronMD - Q9NYI0(PSD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E930Q	TCGA-AC-A23H	BRCA	TCGA	PATTT	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.1944
p.T922S	TCGA-CD-A4MG	STAD	TCGA	PATTT	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.7116
p.V382M	TCGA-D1-A1NZ	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1667
p.V382M	DO41536	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1667
p.E929D	TCGA-D3-A2JL	SKCM	TCGA	PATTT	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.2222
p.T923I	TCGA-DU-6392	LGG	TCGA	PATTT	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.8189
p.A921V	TCGA-VQ-A8P2	STAD	TCGA	PATTT	DEG_SPOP_SBC_1	921:925	Mutation altering degron motif	0.6936
p.K378R	DO6362	CLLE	ICGC	PGTSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.2778
p.S381C	DO233264	GACA	ICGC	PGTSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.S375R	DO228976	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	372:376	Mutation altering degron motif	0.8538
p.P366T	DO229029	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	372:376	Mutation substituting flanking lysine	0.2778
p.Q379K	DO229025	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.25
p.S381R	DO228285	MALY	ICGC	PGTSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.TE369TK	DO220911	MELA	ICGC	PGTSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0
p.R383C	SIDM00845	Burkitt's Lymphoma	GDSC	PGTSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.R383C	SIDM00882	Breast Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1389
p.R916H	SIDM01617	Endometrial Carcinoma	GDSC	PATTT	DEG_SPOP_SBC_1	921:925	Mutation blocking phosphorylation signal	0.6389
p.R916H	ACH-000994	Endometrial/Uterine Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	921:925	Mutation blocking phosphorylation signal	0.6389
p.K912R	ACH-000931	Skin Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	921:925	Mutation rewiring degron network	0.0833

Kaplan plot for PSD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSD3

UniProt ID: Q9NYI0

Entrez ID: 23362

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSD3 in