DegronMD - Q9NZP8(C1RL)

FUNCTION: Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum. {ECO:0000269|PubMed:15358180, ECO:0000269|PubMed:15385675, ECO:0000269|PubMed:15527420}.

GO - Biological processes (BP): complement activation, classical pathway [GO:0006958]; innate immune response [GO:0045087]; zymogen activation [GO:0031638]

GO - Molecular function (MF): serine-type endopeptidase activity [GO:0004252]

GO - Cellular component (CC): blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R329H	TCGA-AB-2868	LAML	TCGA	DYR	CBL_MET	327:329	Mutation altering degron motif	0.8244
p.R329H	DO21595	LAML	ICGC	DYR	CBL_MET	327:329	Mutation altering degron motif	0.8244
p.R329S	TCGA-ER-A19C	SKCM	TCGA	DYR	CBL_MET	327:329	Mutation altering degron motif	0.7427
p.R329S	DO47353	SKCM	ICGC	DYR	CBL_MET	327:329	Mutation altering degron motif	0.7427
p.Q330R	TCGA-DU-6392	LGG	TCGA	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.3056
p.Q330R	DO22237	LGG	ICGC	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.3056
p.V324E	TCGA-55-8205	LUAD	TCGA	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.25
p.V324E	DO48884	LUAD	ICGC	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.25
p.V323I	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.2222
p.V323I	ACH-000694	Esophageal Cancer	CCLE	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.2222
p.V323I	TE-9	oesophagus	COSMIC	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.2222
p.R321H	DO222790	COCA	ICGC	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.1667
p.R321L	DO231075	LUSC	ICGC	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.1667
p.R321L	SIDM00557	Neuroblastoma	GDSC	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.1667
p.R321L	SIDM01005	Acute Myeloid Leukemia	GDSC	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.1667
p.R321L	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.1667
p.R321L	SIDM00410	Other Blood Cancers	GDSC	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.1667
p.R321L	SIDM00324	Neuroblastoma	GDSC	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.1667
p.R321L	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.1667
p.R321L	SIDM00554	Ovarian Carcinoma	GDSC	DYR	CBL_MET	327:329	Mutation rewiring degron network	0.1667

Showing 1 to 20 of 30 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C1RL

UniProt ID: Q9NZP8

Entrez ID: 51279

Protein name: Complement C1r subcomponent-like protein (C1r-LP) (C1r-like protein) (EC 3.4.21.-) (C1r-like serine protease analog protein) (CLSPa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C1RL in