DegronMD - Q9P246(STIM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M507V	TCGA-AJ-A5DW	UCEC	TCGA	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7208
p.G505R	TCGA-DU-6392	LGG	TCGA	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2778
p.G505R	SIDM01394	Kidney Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2778
p.P504S	TCGA-EE-A2GN	SKCM	TCGA	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.25
p.F503L	TCGA-FW-A3R5	SKCM	TCGA	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2222
p.F503Y	TCGA-GN-A8LK	SKCM	TCGA	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2222
p.D502Y	DO25290	LUAD	ICGC	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1944
p.D505H	DO45433	LUSC	ICGC	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2778
p.H506Y	DO219991	SARC	ICGC	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.3056
p.V504A	DO51774	STAD	ICGC	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.25
p.A515T	SIDM00120	Prostate Carcinoma	GDSC	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2222
p.A515T	DU-145	prostate	COSMIC	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2222
p.R516C	ACH-000313	Kidney Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1944
p.A507T	ACH-000979	Prostate Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7139
p.A507T	DU-145	prostate	COSMIC	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7139
p.R516H	ACH-000999	Colon/Colorectal Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1944
p.R516H	SNU-1040	large intestine	COSMIC	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1944
p.R517H	PF-382	haematopoietic and lymphoid tissue	COSMIC	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1667
p.R517H	SNU-1040	large intestine	COSMIC	ARSSS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1667

Kaplan plot for STIM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STIM2

UniProt ID: Q9P246

Entrez ID: 57620

Protein name: Stromal interaction molecule 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STIM2 in