DegronMD - Q9P2N4(ADAMTS9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1323H	TCGA-32-2616	GBM	TCGA	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.1111
p.E1312D	TCGA-53-7813	LUAD	TCGA	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.3056
p.A1319T	TCGA-CG-4460	STAD	TCGA	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.2222
p.A1319T	SIDM01617	Endometrial Carcinoma	GDSC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.2222
p.A1319T	ACH-000994	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.2222
p.P1316L	TCGA-D3-A3C7	SKCM	TCGA	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.3056
p.R1315H	TCGA-EO-A3B0	UCEC	TCGA	DYR	CBL_MET	1313:1315	Mutation altering degron motif	0.8244
p.R1323C	TCGA-FD-A43P	BLCA	TCGA	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.1111
p.R1323C	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.1111
p.R1323C	ACH-002264	Esophageal Cancer	CCLE	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.1111
p.R1323C	KYSE-50	oesophagus	COSMIC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.1111
p.E1312G	TCGA-G3-A25Z	LIHC	TCGA	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.3056
p.R1322Q	DO8159	COAD	ICGC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.1389
p.A1317V	DO222501	COCA	ICGC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.2778
p.G1319R	DO233260	GACA	ICGC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.2222
p.R1322W	DO14478	HNSC	ICGC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.1389
p.R1322W	DO38627	STAD	ICGC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.1389
p.G1307A	DO26752	LUSC	ICGC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.1667
p.V1325A	DO37583	SKCM	ICGC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.0556
p.W1309S	DO41217	UCEC	ICGC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.2222
p.R1317Q	SIDM01314	Colorectal Carcinoma	GDSC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.2778
p.R1317W	SIDM01716	Non-Cancerous	GDSC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.2778
p.R1317W	SIDM00175	Melanoma	GDSC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.2778
p.H1325R	SIDM01088	Endometrial Carcinoma	GDSC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.0556
p.H1325R	ACH-000965	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.0556
p.H1325R	RL95-2	endometrium	COSMIC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.0556
p.R1315C	ACH-001570	Skin Cancer	CCLE	DYR	CBL_MET	1313:1315	Mutation altering degron motif	0.8301
p.C1312Y	639-V	urinary tract	COSMIC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.3056
p.S1314G	PF-382	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	1313:1315	Mutation altering degron motif	0.6993
p.Q1303R	U-CH2	bone	COSMIC	DYR	CBL_MET	1313:1315	Mutation rewiring degron network	0.0556

Kaplan plot for ADAMTS9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAMTS9

UniProt ID: Q9P2N4

Entrez ID: 56999

Protein name: A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAM-TS 9) (ADAM-TS9) (ADAMTS-9) (EC 3.4.24.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAMTS9 in