DegronMD - Q9UBL6(CPNE7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R441Q	TCGA-06-0877	GBM	TCGA	PPKY	ITCH	443:446	Mutation rewiring degron network	0.2778
p.R441Q	DO13108	GBM	ICGC	PPKY	ITCH	443:446	Mutation rewiring degron network	0.2778
p.R441Q	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PPKY	ITCH	443:446	Mutation rewiring degron network	0.2778
p.F433Y	TCGA-W3-AA1V	SKCM	TCGA	PPKY	ITCH	443:446	Mutation rewiring degron network	0.0556
p.F433Y	DO51276	SKCM	ICGC	PPKY	ITCH	443:446	Mutation rewiring degron network	0.0556
p.V448M	TCGA-W3-AA1V	SKCM	TCGA	PPKY	ITCH	443:446	Mutation rewiring degron network	0.2778
p.V448M	DO51276	SKCM	ICGC	PPKY	ITCH	443:446	Mutation rewiring degron network	0.2778
p.L436F	DO229006	LICA	ICGC	PPKY	ITCH	443:446	Mutation rewiring degron network	0.1389
p.A453S	DO229009	LICA	ICGC	PPKY	ITCH	443:446	Mutation rewiring degron network	0.1389
p.R441W	DO232042	ORCA	ICGC	PPKY	ITCH	443:446	Mutation rewiring degron network	0.2778
p.P443L	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	PPKY	ITCH	443:446	Mutation altering degron motif	0.7582
p.P443L	SIDM00701	Non-Cancerous	GDSC	PPKY	ITCH	443:446	Mutation altering degron motif	0.7582
p.E447G	DND-41	haematopoietic and lymphoid tissue	COSMIC	PPKY	ITCH	443:446	Mutation rewiring degron network	0.3056
p.Q435L	NCI-H69	lung	COSMIC	PPKY	ITCH	443:446	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons