DegronMD - Q9UDV6(ZNF212)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S280R	TCGA-2H-A9GO	ESCA	TCGA	VPSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7427
p.P288A	TCGA-78-7156	LUAD	TCGA	VPSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1667
p.P288A	DO23720	LUAD	ICGC	VPSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1667
p.V274A	TCGA-A5-A0G1	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2222
p.V274A	DO42472	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2222
p.R14H	TCGA-AA-3510	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25
p.R14H	TCGA-AA-A00N	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25
p.R14H	DO7783	COAD	ICGC	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25
p.R14H	DO9876	COAD	ICGC	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25
p.R14H	SIDM00217	Colorectal Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25
p.R14H	ACH-000999	Colon/Colorectal Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25
p.R14H	ACH-001395	Breast Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25
p.R14H	SNU-1040	large intestine	COSMIC	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25
p.R11K	TCGA-AG-A002	READ	TCGA	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1667
p.R11K	TCGA-CA-6717	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1667
p.R11K	DO8264	COAD	ICGC	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1667
p.S31I	TCGA-AX-A1CE	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.0556
p.S31I	DO42280	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.0556
p.R11I	TCGA-BS-A0UV	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1667
p.R11I	DO42793	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1667
p.L270V	TCGA-CQ-5333	HNSC	TCGA	VPSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1111
p.L270V	DO14218	HNSC	ICGC	VPSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1111
p.P288L	DO233088	GACA	ICGC	VPSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1667
p.R14L	DO229022	LICA	ICGC	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25
p.G286V	DO229022	LICA	ICGC	VPSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2222
p.S292F	DO222710	MELA	ICGC	VPSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.0556
p.P24S	DO229459	SKCA	ICGC	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25
p.P24S	SIDM01397	Melanoma	GDSC	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25
p.P24S	ACH-000765	Skin Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25
p.A7D	DO229268	THCA	ICGC	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.0556
p.S282G	SIDM00377	Other Sarcomas	GDSC	VPSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.6993
p.S282G	SKN	soft tissue	COSMIC	VPSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.6993
p.S292C	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.0556
p.S292C	ACH-002215	Lymphoma	CCLE	VPSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.0556
p.S292C	BC-3	haematopoietic and lymphoid tissue	COSMIC	VPSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.0556
p.R14C	SIDM00500	Colorectal Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25
p.R14C	ACH-000959	Colon/Colorectal Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25
p.P24H	ACH-001369	Ovarian Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF212

UniProt ID: Q9UDV6

Entrez ID: 7988

Protein name: Zinc finger protein 212 (Zinc finger protein C2H2-150)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF212 in