DegronMD - Q9UEW8(STK39)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q435H	TCGA-69-7980	LUAD	TCGA	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.1111
p.V455A	TCGA-AA-3977	COAD	TCGA	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.0556
p.V455A	DO8730	COAD	ICGC	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.0556
p.D433N	TCGA-AP-A1E0	UCEC	TCGA	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.0556
p.D433N	DO43154	UCEC	ICGC	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.0556
p.Y444H	TCGA-AZ-6601	COAD	TCGA	DYR	CBL_MET	443:445	Mutation altering degron motif	0.834
p.Y444H	DO8119	COAD	ICGC	DYR	CBL_MET	443:445	Mutation altering degron motif	0.834
p.V452M	TCGA-B5-A0JT	UCEC	TCGA	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.1389
p.V452M	DO40802	UCEC	ICGC	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.1389
p.P438H	TCGA-D5-6540	COAD	TCGA	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.1944
p.P438H	DO9708	COAD	ICGC	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.1944
p.E446K	TCGA-DA-A95Z	SKCM	TCGA	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.3056
p.E446K	DO219481	SKCM	ICGC	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.3056
p.N453T	DO233768	GACA	ICGC	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.1111
p.P437T	DO229015	LICA	ICGC	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.1667
p.A440T	DO50879	LICA	ICGC	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.25
p.V455I	DO50880	LICA	ICGC	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.0556
p.Y444C	DO230530	LUSC	ICGC	DYR	CBL_MET	443:445	Mutation altering degron motif	0.8198
p.N439K	DO48901	PBCA	ICGC	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.2222
p.A440S	DO229213	THCA	ICGC	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.25
p.G436S	SIDM00562	Breast Carcinoma	GDSC	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.1389
p.G436S	MRK-nu-1	breast	COSMIC	DYR	CBL_MET	443:445	Mutation rewiring degron network	0.1389

Kaplan plot for STK39 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STK39

UniProt ID: Q9UEW8

Entrez ID: 27347

Protein name: STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STK39 in