DegronMD - Q9UFE4(CCDC39)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S915Y	TCGA-39-5016	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.712
p.S915Y	DO26701	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.712
p.A913V	TCGA-AA-3977	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.5825
p.A913V	DO8730	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.5825
p.R923G	TCGA-BC-A10R	LIHC	TCGA	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1389
p.R923G	TCGA-BC-A10R	LIHC	TCGA	ASSSS	DEG_SPOP_SBC_1	927:931	Mutation rewiring degron network	0.2222
p.R923G	DO22962	LIHC	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1389
p.R923G	DO22962	LIHC	ICGC	ASSSS	DEG_SPOP_SBC_1	927:931	Mutation rewiring degron network	0.2222
p.L907M	TCGA-QQ-A8VH	SARC	TCGA	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1944
p.L907M	DO220262	SARC	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1944
p.S920N	DO227549	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2222
p.S920N	DO227549	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	927:931	Mutation rewiring degron network	0.1389
p.V906L	DO233173	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1667
p.S922F	DO233912	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1667
p.S922F	DO233912	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	927:931	Mutation rewiring degron network	0.1944
p.S936R	DO228952	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	927:931	Mutation rewiring degron network	0.1944
p.S940R	DO229022	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	927:931	Mutation rewiring degron network	0.0833
p.S930R	DO229026	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	927:931	Mutation altering degron motif	0.7427
p.P912S	DO229446	SKCA	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation altering degron motif	0.6752
p.F911L	DO229446	SKCA	ICGC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.3056
p.E908A	SIDM01090	Colorectal Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2222
p.E908A	RKO	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.2222
p.V934D	SIDM00491	Thyroid Gland Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	927:931	Mutation rewiring degron network	0.25
p.V934D	ASH-3	thyroid	COSMIC	ASSSS	DEG_SPOP_SBC_1	927:931	Mutation rewiring degron network	0.25
p.V934I	SIDM00491	Thyroid Gland Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	927:931	Mutation rewiring degron network	0.25
p.V934I	ASH-3	thyroid	COSMIC	ASSSS	DEG_SPOP_SBC_1	927:931	Mutation rewiring degron network	0.25
p.S902Y	SIDM01149	Small Cell Lung Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.0556
p.S902Y	ACH-001365	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.0556
p.S902Y	NCI-H847	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.0556
p.P924S	SIDM00980	Gastric Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1111
p.P924S	SIDM00980	Gastric Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	927:931	Mutation rewiring degron network	0.25
p.P924S	ACH-000948	Gastric Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1111
p.P924S	ACH-000948	Gastric Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	927:931	Mutation rewiring degron network	0.25
p.P924S	23132-87	stomach	COSMIC	PASSS	DEG_SPOP_SBC_1	912:916	Mutation rewiring degron network	0.1111
p.P924S	23132-87	stomach	COSMIC	ASSSS	DEG_SPOP_SBC_1	927:931	Mutation rewiring degron network	0.25

Kaplan plot for CCDC39 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC39

UniProt ID: Q9UFE4

Entrez ID: 339829

Protein name: Coiled-coil domain-containing protein 39

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC39 in