DegronMD - Q9UGC6(RGS17)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I195V	TCGA-B5-A1MR	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0833
p.I195V	DO41758	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0833
p.I195M	TCGA-EO-A3B0	UCEC	TCGA	AGSSS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0833
p.I195M	DO219773	UCEC	ICGC	AGSSS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0833
p.Q194E	TCGA-FU-A23L	CESC	TCGA	AGSSS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0556
p.Q194E	DO6278	CESC	ICGC	AGSSS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.0556
p.S206Y	TCGA-NC-A5HM	LUSC	TCGA	AGSSS	DEG_SPOP_SBC_1	204:208	Mutation altering degron motif	0.712
p.S206Y	DO219195	LUSC	ICGC	AGSSS	DEG_SPOP_SBC_1	204:208	Mutation altering degron motif	0.712
p.S210Y	DO229037	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.2778
p.T203I	DO229054	LICA	ICGC	AGSSS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.3056
p.E209D	SIDM00201	Ewing's Sarcoma	GDSC	AGSSS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.3056
p.E209D	ACH-002119	Bone Cancer	CCLE	AGSSS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.3056
p.E209D	EW-7	bone	COSMIC	AGSSS	DEG_SPOP_SBC_1	204:208	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons