DegronMD - Q9UGN4(CD300A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S153Y	TCGA-AC-A23H	BRCA	TCGA	PVSST	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.712
p.S153Y	DO2401	BRCA	ICGC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.712
p.S130T	TCGA-AO-A03V	BRCA	TCGA	PASTS	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.6005
p.A138V	TCGA-AX-A2HD	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1111
p.A138V	SIDM00269	Ewing's Sarcoma	GDSC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1111
p.A138V	SIDM01201	Other Blood Cancers	GDSC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1111
p.A138V	SIDM00507	Other Solid Cancers	GDSC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1111
p.T141I	TCGA-BG-A0MG	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.T141I	TCGA-D3-A8GI	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.T141I	DO50284	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.T141I	DO42057	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.H163N	TCGA-BR-6566	STAD	TCGA	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.H163N	DO38217	STAD	ICGC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.I144L	TCGA-BS-A0UF	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1667
p.I144L	DO41488	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1667
p.S152L	TCGA-D3-A2JA	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7667
p.S152L	TCGA-W3-AA1V	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7667
p.S152L	DO220907	MELA	ICGC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7667
p.S152L	DO222653	MELA	ICGC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7667
p.S152L	DO47652	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7667
p.S152L	DO51276	SKCM	ICGC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7667
p.P150H	TCGA-DU-6392	LGG	TCGA	PVSST	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7694
p.K140N	TCGA-E6-A1LX	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	126:130	Mutation substituting flanking lysine	0.1667
p.K140N	TCGA-E6-A1LX	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	150:154	Mutation substituting flanking lysine	0.1667
p.K140N	DO41020	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation substituting flanking lysine	0.1667
p.K140N	DO41020	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation substituting flanking lysine	0.1667
p.H163L	TCGA-EB-A3Y7	SKCM	TCGA	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.P126Q	TCGA-EE-A20F	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.7035
p.P126Q	DO37961	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.7035
p.P116L	TCGA-EE-A2MR	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.0556
p.P116L	DO37819	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.0556
p.S125F	DO550	BLCA	ICGC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.3056
p.S125F	HT-3	cervix	COSMIC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.3056
p.R129S	DO14133	GBM	ICGC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.7427
p.S145T	DO50930	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1944
p.M131K	DO231040	LUSC	ICGC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.3056
p.R136Q	DO41235	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1667
p.A127V	SIDM00578	Neuroblastoma	GDSC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.5825
p.V118I	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1111
p.V118I	ACH-000825	Lung Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1111
p.V118I	HOP-92	lung	COSMIC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1111
p.V117I	SIDM00391	Plasma Cell Myeloma	GDSC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.0833
p.V117I	SK-MM-2	haematopoietic and lymphoid tissue	COSMIC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.0833
p.T143A	SIDM00035	Thyroid Gland Carcinoma	GDSC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1389
p.T143A	S-117	soft tissue	COSMIC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1389
p.S139L	ACH-000805	Skin Cancer	CCLE	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.0833
p.S139L	COLO-679	skin	COSMIC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.0833
p.R155Q	ACH-001001	Bone Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.3056
p.S144F	ACH-001525	Cervical Cancer	CCLE	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1667
p.S144F	HT-3	cervix	COSMIC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1667
p.S156L	COLO-679	skin	COSMIC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2778
p.P132Q	H513	pleura	COSMIC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.2778
p.S161F	HT-3	cervix	COSMIC	PVSST	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1389
p.S120L	COLO-679	skin	COSMIC	PASTS	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1667

Kaplan plot for CD300A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CD300A

UniProt ID: Q9UGN4

Entrez ID: 11314

Protein name: CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CD300A in